FlyBase Allele Report: Dmel\trn[S064117]

General Information

Symbol

Dmel\trn^S064117

Species

D. melanogaster

Name

FlyBase ID

FBal0082153

Feature type

allele

Associated gene

Dmel\trn

Associated Insertion(s)

P{lacW}trn^S064117

Carried in Construct

Also Known As

trn-lacZ, tartan-lacZ

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Deak et al., 1997)

P-element activity

(Salzberg et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{lacW}trn^S064117

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

trn

(Milan et al., 2002)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-231.UAS}

(Onur et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | recessive

(Kurusu et al., 2008)

lethal | recessive

(Deak et al., 1997)

lethal - all die during embryonic stage | recessive

(Salzberg et al., 1997)

some die during embryonic stage | recessive

(Salzberg et al., 1997)

Phenotype Manifest In

larval abdominal lch5 neuron | embryonic stage

(Salzberg et al., 1997)

larval intersegmental nerve branch ISNb of A1-7

(Kurusu et al., 2008)

larval segmental nerve branch SNa of A1-7

(Kurusu et al., 2008)

Detailed Description

Statement

Reference

trn^S064117 homozygous embryos have motor axon guidance defects that primarily affect the ISNb and SNa nerves.

(Kurusu et al., 2008)

Early lethal.

(Deak et al., 1997)

Embryos exhibit occasional dorsalization of LCh5. Transheterozygotes with trn^S002405a are semilethal.

(Salzberg et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

trn^S064117 has abnormal neuroanatomy | recessive phenotype, enhanceable by caps^65.2/caps^65.2

(Kurusu et al., 2008)

Suppressed by

Statement

Reference

caps^65.2, trn^S064117 has abnormal neuroanatomy | recessive phenotype, suppressible | partially by Scer\GAL4^en-e16E/trn^UAS.cMa

(Kurusu et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

trn^S064117 has larval intersegmental nerve branch ISNb of A1-7 phenotype, enhanceable by caps^65.2/caps^65.2

(Kurusu et al., 2008)

trn^S064117 has larval segmental nerve branch SNa of A1-7 phenotype, enhanceable by caps^65.2/caps^65.2

(Kurusu et al., 2008)

Suppressed by

Statement

Reference

caps^65.2, trn^S064117 has larval segmental nerve branch SNa of A1-7 phenotype, suppressible | partially by Scer\GAL4^en-e16E/trn^UAS.cMa

(Kurusu et al., 2008)

caps^65.2, trn^S064117 has larval intersegmental nerve branch ISNb of A1-7 phenotype, suppressible | partially by Scer\GAL4^en-e16E/trn^UAS.cMa

(Kurusu et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The penetrance of axon guidance defects affecting ISNb and SNa in trn^S064117 homozygous embryos is significantly enhanced by caps^65.2/caps^65.2. In around 20% of these ISNb, a single axon forms a distinctive terminal loop whose distal-most point is at muscle 13. These axon guidance defects are significantly rescued/suppressed by trn^Scer\UAS.cMa; Scer\GAL4^en-e16E.

(Kurusu et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

4550

y¹ w^67c23; P{lacW}trn^S064117/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

Comments

Δ2-3 induced reversion demonstrates the insertion is responsible for the lethal phenotype.

(Salzberg et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

0641/17

(Deak et al., 1997)

641/17

(Salzberg et al., 1997)

l(3)S064117

(Bloomington Drosophila Stock Center, 1998.6.3)

trn^LOF

(Onur et al., 2021)

trn^S064117

(Sharrock et al., 2022, Roy et al., 2014, Kohsaka and Nose, 2009)

trn^s064117

(Kurusu et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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