FlyBase Allele Report: Dmel\ds[55]

General Information

Symbol

Dmel\ds⁵⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0003129

Feature type

allele

Associated gene

Dmel\ds

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(Clark et al., 1995)

Mutagen

X ray

(Clark et al., 1995)

Progenitor genotype

Caused by aberration

In(2L)SM5-1

In(2LR)SM5

Cytology

Description

Inversion breakpoint (21E2 breakpoint of In(2L)SM5-1) is in 1st intron of ds. The 5' (distal) end of this breakpoint corresponds to 2L:675 ,190 and the 3' (proximal) end corresponds to 2L:675 ,187 (release 6 coordinates), meaning that 4bp of genomic sequence is duplicated at this breakpoint.

(Miller et al., 2018)

Break at 21D falls within the large intron of ds. Predicted product will be a secreted and truncated protein.

(Clark et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

anterior crossvein

(Clark et al., 1995)

eye

(Clark et al., 1995)

leg

(Clark et al., 1995)

thorax

(Clark et al., 1995)

wing

(Clark et al., 1995)

Detailed Description

Statement

Reference

In addition to 100% penetrant defects in leg, wing and thorax, rough patches in the eye appear at low frequency. Anterior crossvein is displaced posteriorly. Combinations of ds^33k and ds⁵⁵ with each other or with Df(2L)S2 or Df(2L)ast1 eclose with very low frequency and show very strong deformations of thorax, legs and wings.

(Clark et al., 1995)

RK2.

(Craymer, 1980)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ds⁵⁵ is an enhancer of visible phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

ds⁵⁵ is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, arm^UAS.cWa

(Greaves et al., 1999)

Suppressor of

Statement

Reference

ds⁵⁵ is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

ds⁵⁵ is a suppressor of visible phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

ds⁵⁵ is an enhancer of wing phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

ds⁵⁵ is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, arm^UAS.cWa

(Greaves et al., 1999)

Suppressor of

Statement

Reference

ds⁵⁵ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

ds⁵⁵ is a suppressor of wing phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

ds⁰⁵¹⁴²

(Couso, 2000.2.10)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Craymer. R. F. Grell, 1955.

Craymer.

(Craymer, 1980)

Cramer.

(Clark et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ds55

(Greaves et al., 1999)

ds⁵⁵

(Miller et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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