if you want to try and bag on gen-x you're going to have to put a bit more work into it than this.

Dan Regan

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Clinical, Histopathological and Genetic Features of a Cutaneous Adnexal Polycystic Syndrome in Lykoi Cats: A Prospective Study of 10 Cases

Objectives

The Lykoi is a recently recognised feline breed with a unique coat phenotype caused by six variants of the Hairless (HR) gene. A specific severe cutaneous comedonal syndrome has been reported in this breed. The aim of the study was to carry out a clinical, histopathological and genetic characterisation of this syndrome.

Methods

Prospective data collection included clinical evaluation, skin biopsies for histopathology, trichoscopic examination of hair shafts, blood sampling for haematology and biochemistry, cutaneous swabs for bacteriological culture, and buccal swabs for DNA extraction and genotyping.

Results

In total, 11 privately owned Lykoi cats were enrolled, including those with varying degrees of skin involvement and one healthy cat. Cats were aged 1.5–7 years at the time of diagnosis. Clinical presentation was characterised by papular lesions and comedones, ranging from severe generalised forms (n = 6/10) to moderate regional forms (n = 2/10) and to mild scattered forms (n = 2/10). Histopathological lesions from skin biopsies revealed infundibular follicular cysts (n = 9/10), sebaceous gland (duct) cysts (n = 10/10) and sweat gland cysts (n = 5/10). Genetic analysis identified 5/6 described HR variants among the 10 affected Lykoi and the control Lykoi.

Conclusions and Relevance

This cutaneous syndrome shows a variable clinical severity that is not fully explained by genotype alone. The consistent presence of cysts from all three adnexal structures, even in clinically unaffected skin, supports the recognition of a novel skin condition, which we propose to name cutaneous adnexal polycystic syndrome (CAPS) in Lykoi cats. Further research is needed to elucidate its pathogenesis.

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I strongly encourage you to read the full study, it’s extremely interesting - although be warned, it does have visuals.

I’ve talked about the Lykoi breed before and I’m glad they’re finally getting more attention, I hope further research is done into CAPS.

Something I thought was interesting was how the asymptomatic Lykoi had an isolated sebaceous duct cyst, she is 3y at the time the sample was collected and the most common age of symptom onset appears to be 3.5y - 4y.

Will she still be subclinical a year from the study?

SR-71 lands at Kadena AB Okinawa

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Not the answer I expected

You’re not depressed. You just need $250,000 in your bank account.

the most intense form of misogyny is telling women astrology isn't real

Single Serve Brownie

I wanted to make my dad his own giant chocolate chip cookie for his birthday, and, after having a browse on Pinterest, this recipe seemed the most promising.

I made this in full using light brown sugar and semi-sweet chocolate chips. I thought that the easiest thing to do would be to take advantage of the stand mixer, but, honestly, with such a small volume, I think the hand mixer or even just hand whisking would have been quicker and more effective.

At the point where I added the dry ingredients, I was a little concerned, as the dough seemed kind of dry and crumbly and not quite at that cookie dough consistency. But after folding a few times to get the chocolate chips mixed in, things were looking a lot better, so I forged ahead.

Despite all of this, I have to say, I genuinely think this is a perfect chocolate chip cookie recipe. 15 minutes was the perfect time, and the final texture was just gorgeous, slightly crisped on the outside, but beautifully soft elsewhere. I only had a couple of bites, as this was really all for my dad, but I genuinely think this may be one of the best chocolate chip cookies I've ever made, single serve or otherwise — and we in this family are chocolate chip cookie connoisseurs!

Single Serve Chocolate Chip Cookie

Single Serve Pistachio Cream Chocolate Chip Cookie