Talk:MBDB
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Cleaned
editFolks lets please sound at least sound moderatly smart in drug articles. No reason to give the DEA fuel. I had to clean this article of all "yous" and other sentances addressing the reader. This is an encyclopedia not a how to guide.
Quote: "Just like with MDMA, if you must use the drug, it's best to make sure you're hydrated at all times and take occasional breaks from dancing or other strenuous activities. Dosage, according to PiHKAL, is 180-210 mg; the proper doasge relative to body mass seems unknown. A good starting dose for an inexperienced user is around the 150mg range. If the user has done MDMA before, then using the dose according to PiHKAL is a good starting dose."
This is just awful. In the future read better written pages like the one on mdma before editing. Second, for gods sake do not use slang. "If the user has done mdma"? Fuck. No one will take that serious. That was written poorly and does not contribute to the article so I have deleted it.
N-methyl analogue?
editIsn't it unnecessary or improper to say "[MBDB] is the alpha-ethyl-N-methyl analog of MDMA (Esctasy)" when MDMA is already N-methylated. Perhaps it should be "...analogue of MDA" or the "N-methyl" should be removed. I'm going to remove the "N-methyl" portion but if I am mistaking please clarify. --Astavats (talk) 22:33, 1 March 2008 (UTC)
Why does MDBD redirect here?
editI'm going to remove the redirect from MDBD and flag it for deletion. Isn't it true that the correct abbreviation is MBDB? Klortho (talk) 01:01, 12 November 2012 (UTC)
This sentence fails math.
edit"Its EC50Tooltip half-maximal effective concentration values for induction of monoamine release are 540 nM for serotonin, 3,300 nM for norepinephrine (6.1-fold lower than for serotonin), and >100,000 for dopamine (>185-fold lower than for serotonin)."
I tried to follow the citation for this sentence, but the abstract didn't give an indication of where the mistake lies. The European Journal of Pharmacology has the numbers behind the paywall. Taking the sentence at face value, 540nM is a lower EC50 than 3300nM (6.1 times lower) and 100,000nM (185 times lower). 540nM is attributed here to serotonin, while 3300nM and >100,000nM are attributed to NE and DA, respectively. It follows then that an EC50 of 3300nM for induction of norepinephrine release is 6.1 times higher than the EC50 of 540nM for induction of serotonin release, and an EC50 of >100,000nM for induction of dopamine release is 185 time higher than 540nM for induction of serotonin release. Given that this sentence is offered in support of the idea that MDBD is a serotonin and norepinephrine releasing agent, but not a dopamine releasing agent, which is reflected in the abstract of the cited journal article, it seems that the mistake is with the two uses of the word "lower" when "higher" was what was meant. 2600:8802:2A0A:CE00:F176:BCB5:5E05:6E25 (talk) 23:46, 22 September 2025 (UTC)