TPTE

Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.

TPTE
Identifiers
Aliases	TPTE, CT44, PTEN2, transmembrane phosphatase with tensin homology
External IDs	OMIM: 604336; GeneCards: TPTE; OMA:TPTE - orthologs
Gene location (Human) Chr. Chromosome 21 (human) Band 21p11.2 Start 10,521,553 bp End 10,606,140 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis testicle gonad placenta renal cortex right lobe of thyroid gland left lobe of thyroid gland body of stomach anterior pituitary n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein tyrosine phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity Cellular component integral component of membrane membrane Biological process signal transduction dephosphorylation peptidyl-tyrosine dephosphorylation protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7179 n/a Ensembl ENSG00000274391 n/a UniProt P56180 n/a RefSeq (mRNA) NM_199261 NM_001290224 NM_199259 NM_199260 n/a RefSeq (protein) NP_001277153 NP_954868 NP_954869 NP_954870 n/a Location (UCSC) Chr 21: 10.52 – 10.61 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Function

TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids. TPTE is a primate-specific duplicate of the TPTE2 (TPIP) inositol phospholipid phosphatase; TPTE itself is predicted to lack phosphatase activity. TPTE and TPTE2 are the mammalian homologues to the subfamily of voltage sensitive phosphatases.

Further reading

• Antonarakis SE (July 1998). "10 years of Genomics, chromosome 21, and Down syndrome". Genomics. 51 (1): 1–16. doi:10.1006/geno.1998.5335. PMID 9693027.
• Chen H, Rossier C, Morris MA, Scott HS, Gos A, Bairoch A, et al. (November 1999). "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y". Human Genetics. 105 (5): 399–409. doi:10.1007/s004390051122 (inactive 21 October 2025). PMID 10598804.{{cite journal}}: CS1 maint: DOI inactive as of October 2025 (link)
• Guipponi M, Yaspo ML, Riesselman L, Chen H, De Sario A, Roizès G, et al. (August 2000). "Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21" (PDF). Human Genetics. 107 (2): 127–131. doi:10.1007/s004390000343. PMID 11030409. S2CID 29304641.
• Wu Y, Dowbenko D, Pisabarro MT, Dillard-Telm L, Koeppen H, Lasky LA (June 2001). "PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase". The Journal of Biological Chemistry. 276 (24): 21745–21753. doi:10.1074/jbc.M101480200. PMID 11279206.
• Guipponi M, Tapparel C, Jousson O, Scamuffa N, Mas C, Rossier C, et al. (December 2001). "The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family" (PDF). Human Genetics. 109 (6): 569–575. doi:10.1007/s004390100607. PMID 11810268. S2CID 8267495.