(S)-scoulerine 9-O-methyltransferase (EC 2.1.1.117) is an enzyme that catalyzes the chemical reaction
| (S)-scoulerine 9-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.117 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
-Isocorypalmine.svg)
This is a methylation reaction in which the benzylisoquinoline alkaloid, (S)-scoulerine, is converted to (S)-isocorypalmine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Berberis wilsoniae.[1]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase. It is part of the alkaloid biosynthesis pathway.[2]
References
edit- ↑ Muemmler S, Rueffer M, Nagakura N, Zenk MH (1985). "S-Adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase, a highly stereo- and regiospecific enzyme in tetrahydroberberine biosynthesis". Plant Cell Reports. 4 (1): 36–39. doi:10.1007/BF00285501. PMID 24253642.
- ↑ Enzyme 2.1.1.117 at KEGG Pathway Database.
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