MEF2D

Protein sy'n cael ei godio yn y corff dynol gan y genyn MEF2D yw MEF2D a elwir hefyd yn Myocyte enhancer factor 2D (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q22.

MEF2D
Dynodwyr
Cyfenwau	MEF2D, myocyte enhancer factor 2D
Dynodwyr allanol	OMIM: 600663 HomoloGene: 4327 GeneCards: MEF2D
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein dimerization activity • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • histone deacetylase binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • enzyme binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • intracellular membrane-bounded organelle • nucleoplasm • cnewyllyn cell Prosesau biolegol • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • chondrocyte differentiation • adult heart development • muscle organ development • endochondral ossification • transcription by RNA polymerase II • transcription, DNA-templated • nervous system development • multicellular organism development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • osteoblast differentiation • skeletal muscle cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0097285 apoptotic process • positive regulation of vascular associated smooth muscle cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4209	n/a
Ensembl	ENSG00000116604	n/a
UniProt	Q14814	n/a
RefSeq (mRNA)	NM_001271629 NM_005920	n/a
RefSeq (protein)	NP_001258558 NP_005911	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Llyfryddiaeth

• "Myocyte enhancer factor 2D provides a cross-talk between chronic inflammation and lung cancer. ". J Transl Med. 2017. PMID 28340574.
• "Myocyte enhancer factor 2D promotes tumorigenicity in malignant glioma cells. ". Tumour Biol. 2016. PMID 26234765.
• "MEF2D overexpression contributes to the progression of osteosarcoma. ". Gene. 2015. PMID 25814384.
• "miR-218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D. ". Oncol Rep. 2015. PMID 25812649.
• "Overexpression of the transcription factor MEF2D in hepatocellular carcinoma sustains malignant character by suppressing G2-M transition genes.". Cancer Res. 2014. PMID 24390737.