Table of Contents
Reviews
Human brain slice cultures: translational applications and ethical considerationsThis review outlines the scientific utility and ethical imperatives of human brain slice cultures, calling for global ethical standards in ex vivo neuroscience research.
Research Articles
Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotypeThis study shows that overexpression of the acetyltransferases ATase1 and ATase2 in the mouse alters the quality of the secretory pathway causing a progeria-like phenotype.
Longer internal exons tend to have more tandem repeats and more frequently experience insertions and deletionsWe found that insertions and deletions occur more frequently in longer internal exons and mostly encode structure-less regions, and that half of them are attributable to alterations in tandem repeats.
Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromasSHP2 inhibition targets monocyte-derived neurofibroma tumor-associated macrophages. Adjusting time of drug administration modulates adaptive immunity and improves treatment efficacy. SHP2 inhibition may be a general strategy to target benign tumors in which T cells and myeloid cells are pro-tumorigenic.
Antioxidant properties of dihydroxy B-ring flavonoids modulate circadian amplitude in ArabidopsisFlavonoids, plant compounds with antioxidant properties, regulate the internal biological clock in Arabidopsis plants by modulating cellular levels of reactive oxygen species.
Lnk/Sh2b3 regulates initiation and severity of autoimmune insulitis and contributes to diabetes riskVariant of Lnk/SH2B3 adaptor has been reported as a risk for several autoimmune diseases, including type 1 diabetes. We found Lnk prevents abnormal activation of DCs by GM-CSF followed by autocrine IL-27/IL-27R loops and protects individuals from developing autoimmune diabetes.
Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypesADAMTS10 and ADAMTS17 regulate bone growth and extracellular matrix formation by promoting secretion and deposition of fibronectin, fibrillin-1, and collagen type VI.
KANSL3 directs transcriptional programs essential for hepatic metabolism and differentiationKANSL3 is an epigenetic regulator of hepatocyte metabolism and differentiation, essential for liver development and key to maintaining liver health.
Beneficial and detrimental consequences of AHR activation in intestinal infectionAHR activation can positively or negatively affect immune responses. Here, we investigate whether TCDD toxicity is due to prolonged duration of AHR activation and show that duration of stimulation is not responsible on its own.
A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodelingThis study focuses on schizophrenia-related genes in a genetically tractable system and identifies the requirement of both glial and neuronal MMPs during developmental remodeling.
PARP10 is critical for stress granule initiationThis study identifies PARP10 as a key regulator of stress granule assembly by ADP-ribosylating G3BP1 and modulating eIF2α phosphorylation and translation factor recruitment.
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levelsThis study investigates effects of increased POLRMT levels and reports stimulation of mtDNA transcription initiation and enhanced exercise capacity without an effect on steady-state mRNA levels.
DA-Raf synergistically binds to the plasma membrane and Ras to suppress ERK signalingDA-Raf efficiently associates with the plasma membrane phosphatidylserine via the RBD and CRD domains and thus predominates over Raf proteins in the binding to Ras, thereby preventing the ERK pathway.
Resources
Predicting nonsense-mediated mRNA decay from splicing events in sepsis using RNA-sequencing dataA computational analysis of alternative splicing and nonsense-mediated decay using critically ill patients’ RNA-sequencing data can elucidate sepsis transcriptomics and potentially associated protein targets.
