Newest Articles
Conserved 3D genome reorganization during DNA repairThis review synthesizes findings from genomic, molecular, and disease studies that chromatin organization dynamically shapes diverse DNA repair pathways, with translational potential for therapeutic intervention.
- Correction: Transient PU.1 low fetal progenitors generate lymphoid progeny that contribute to adult immunity
Transient PU.1low fetal progenitors generate activated and memory T and B cells that colonize and are maintained in secondary lymphoid tissues and make an early and long-term contribution to the adult immune system.
GPR88 localization to primary cilia in neurons is cell-type specificThis is the first demonstration of cell-type specific GPCR localization to primary cilia in vivo in intact brain tissue.
TRPM7 and magnesium orchestrate human CD4 T-cell activation and differentiationThe ion channel-kinase TRPM7 maintains intracellular Mg2+ homeostasis, affects early Ca2+ signals, influences downstream Ca2+-dependent signaling pathways and thus is crucial for T-cell activation and differentiation. By modulating AKT/SMAD2 signaling, TRPM7 acts as a molecular switch to balance Treg/TH17 polarization.
- Correction: Proteomic-based stratification of intermediate-risk prostate cancer patients
This study demonstrates the ability of a protein-based signature to risk-stratify prostate cancer patients with Gleason grade groups 2 and 3 and predict the risk of biochemical recurrence.
The unfolded protein response in progeria arteries originates from non-endothelial cell typesProgeroid endothelial cells do not show a robust activation of the unfolded protein response, contrary to what has been reported in other arterial cell types such as vascular smooth muscle cells.
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