I upgraded from Debian stable (Stretch) to testing (Buster) today, which went without a hitch. All applications work fine, except Firefox, which has awful font rendering: text is often hard to read and has artifacts. It gets better with (much) higher zoom values than 100%, but artifacts are always visible. (I'm still running Firefox 55 because I'm missing lots of add-ons in quantum. Many still cannot be implemented in the new system because APIs are todo.)
Screenshot I've found online with the same issue, except this is for Firefox 52: