Odds are you need to have the UrlRewriter module installed for IIS and then you need to have the following in your web.config at system.webServer/rewrite/rules
<rule name="Angular Routes" stopProcessing="true">
<match url=".*" />
<conditions logicalGrouping="MatchAll">
<add input="{REQUEST_FILENAME}" matchType="IsFile" negate="true" />
<add input="{REQUEST_FILENAME}" matchType="IsDirectory" negate="true" />
<add input="{REQUEST_URI}" pattern="^/(api)" negate="true" />
</conditions>
<action type="Rewrite" url="/Home/Index?url={UrlEncode:{R:0}}" />
</rule>
The specifics of the rewrite rule though will depend on your app. I'm hooking up my angular root html node in my Home/Index view. If you are doing that differently, you will have to update it to route to where you are expecting it to go.
Angular docs