You can filter your A objects that satisfy this condition with:
A.objects.filter(a__b__some_field=True)
This will generate a query that looks, more or less like:
SELECT a.*
FROM a
JOIN b ON a.a_id = b.id
JOIN c ON b.b_id = c.id
WHERE c.some_field = 1
The double underscore (__) can be used to look "through" relations (like ForeignKeys, OneToOneFields and ManyToManyFields). In case it is ...-to-many field, this is existentially quantified. But here the ForeignKeys are many-to-one relations, so that does not matter.
  Note: ForeignKeys to B (or C) is typically named b (or c), not a (or b), since that is the name of the current model. The name of a relation typically specifies how the object(s) it targets relate to the current model.