Consider Many-to-One relationship: Article-to-Keyword.
An article has only one keyword, single keyword can be referenced by multiple articles.
class Article(Base):
    __tablename__ = 'article'
    id = Column(Integer, primary_key=True)
    keyword_id = Column(Integer, ForeignKey('keyword.id'))
    keyword = relationship("Keyword")
class Keyword(Base):
    __tablename__ = 'keyword'
    id = Column(Integer, primary_key=True)
    name = Column(String, nullable=False, unique=True)
Now, I'd like to be able to associate multiple instances of Keyword having the same name value
with the sole row in keyword table.  
So that saving a1 and a2:
a1 = Article()
a1.keyword = Keyword(name="science")
a2 = Article()
a2.keyword = Keyword(name="science")
Wouldn't yield unique constraint violation.
Currently one has to create additional query fetching FK from keyword table and set it in Article object as Article.keyword_id.
Gets pretty boring with real-world schemas.