(Q34623788)

3 August 2017

title

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling (English)

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Gene Ontology release 2020-05-02

3 August 2017

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Stephen P Jackson

2

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author name string

Damien D'Amours

series ordinal

1

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3 August 2017

publication date

1 May 2002

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Nature Reviews Molecular Cell Biology

3 August 2017

language of work or name

English

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published in

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3 August 2017

volume

3

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3 August 2017

issue

5

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3 August 2017

page(s)

317-327

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publication type of scholarly work

3 August 2017

review article

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The isolation, genetics and survival characteristics of ultraviolet light-sensitive mutants in yeast

cites work

1 reference

Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae

31 March 2020

1 reference

Recombination-induced CAG trinucleotide repeat expansions in yeast involve the MRE11-RAD50-XRS2 complex

31 March 2020

1 reference

The yeast Xrs2 complex functions in S phase checkpoint regulation

31 March 2020

1 reference

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

31 March 2020

1 reference

Positional cloning of the gene for Nijmegen breakage syndrome

31 March 2020

1 reference

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

31 March 2020

1 reference

Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group

31 March 2020

1 reference

The Mre11 complex and ATM: collaborating to navigate S phase

31 March 2020

1 reference

Hypersensitivity of cells from a new chromosomal-breakage syndrome to DNA-damaging agents

31 March 2020

1 reference

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

31 March 2020

1 reference

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

31 March 2020

1 reference

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

31 March 2020

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Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice

31 March 2020

1 reference

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

31 March 2020

1 reference

Complex formation and functional versatility of Mre11 of budding yeast in recombination

31 March 2020

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Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance

31 March 2020

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Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

31 March 2020

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Distinct roles of two separablein vitroactivities of yeast Mre11 in mitotic and meiotic recombination

31 March 2020

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The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks

31 March 2020

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Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast.

31 March 2020

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Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

31 March 2020

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DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

31 March 2020

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

31 March 2020

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A mechanistic basis for Mre11-directed DNA joining at microhomologies

31 March 2020

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DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways

31 March 2020

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Human Rad50/Mre11 is a flexible complex that can tether DNA ends

31 March 2020

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Promotion of Dnl4-Catalyzed DNA End-Joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 Complexes

31 March 2020

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Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair

31 March 2020

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

31 March 2020

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Superfamily of UvrA-related NTP-binding proteins. Implications for rational classification of recombination/repair systems

31 March 2020

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Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

31 March 2020

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The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair

31 March 2020

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Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy

31 March 2020

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Replication, recombination, and repair: going for the gold

31 March 2020

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Genetic control of diploid recovery after gamma-irradiation in the yeast Saccharomyces cerevisiae

31 March 2020

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Recombinationless meiosis in Saccharomyces cerevisiae

31 March 2020

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The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors

31 March 2020

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The FHA domain is a modular phosphopeptide recognition motif.

31 March 2020

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The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

31 March 2020

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In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts

31 March 2020

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hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

31 March 2020

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Polymerase eta deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair

31 March 2020

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DNA damage-dependent nuclear dynamics of the Mre11 complex

31 March 2020

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Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis

31 March 2020

1 reference

NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

31 March 2020

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

31 March 2020

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Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

31 March 2020

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AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

31 March 2020

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UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, γ-H2AX formation, and Mre11 relocalization

31 March 2020

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The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage

31 March 2020

1 reference

Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype.

31 March 2020

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

31 March 2020

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

31 March 2020

1 reference

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

31 March 2020

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

31 March 2020

1 reference

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication

31 March 2020

1 reference

Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast

31 March 2020

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Trinucleotide repeats affect DNA replication in vivo

31 March 2020

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Expansion and Length-Dependent Fragility of CTG Repeats in Yeast

31 March 2020

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Repair by recombination of DNA containing a palindromic sequence

31 March 2020

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Homologous recombination is required for the viability of rad27 mutants

31 March 2020

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Links between replication and recombination in Saccharomyces cerevisiae: a hypersensitive requirement for homologous recombination in the absence of Rad27 activity.

31 March 2020

1 reference

A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae

31 March 2020

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mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis

31 March 2020

1 reference

A Novel mre11 Mutation Impairs Processing of Double-Strand Breaks of DNA during Both Mitosis and Meiosis

31 March 2020

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Localisation of RAD50 and MRE11 in spermatocyte nuclei of mouse and rat

31 March 2020

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The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae

31 March 2020

1 reference

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

31 March 2020

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Effect of mutations in genes affecting homologous recombination on restriction enzyme-mediated and illegitimate recombination in Saccharomyces cerevisiae

31 March 2020

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Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae

31 March 2020

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Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

31 March 2020

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Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe.

31 March 2020

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Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome

31 March 2020

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V(D)J rearrangement in Nijmegen breakage syndrome

31 March 2020

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Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

31 March 2020

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RAD51 is required for the repair of plasmid double-stranded DNA gaps from either plasmid or chromosomal templates

31 March 2020

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Alteration of gene conversion tract length and associated crossing over during plasmid gap repair in nuclease-deficient strains of Saccharomyces cerevisiae

31 March 2020

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The Saccharomyces cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non-homologous end joining

31 March 2020

1 reference

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

31 March 2020

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Nijmegen Breakage Syndrome Cells Fail To Induce the p53-Mediated DNA Damage Response following Exposure to Ionizing Radiation

31 March 2020

1 reference

Radiation Induction of p53 in Cells from Nijmegen Breakage Syndrome Is Defective but Not Similar to Ataxia-Telangiectasia

31 March 2020

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Impaired p53-mediated DNA damage response, cell-cycle disturbance and chromosome aberrations in Nijmegen breakage syndrome lymphoblastoid cell lines.

31 March 2020

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Chk2 activation dependence on Nbs1 after DNA damage

31 March 2020

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

31 March 2020

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SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

31 March 2020

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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

31 March 2020

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Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex

31 March 2020

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Yeast checkpoint genes in DNA damage processing: implications for repair and arrest

31 March 2020

1 reference

Saccharomyces Ku70, Mre11/Rad50, and RPA Proteins Regulate Adaptation to G2/M Arrest after DNA Damage

31 March 2020

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Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest.

31 March 2020

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Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair

31 March 2020

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Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae

31 March 2020

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Telomere maintenance is dependent on activities required for end repair of double-strand breaks

31 March 2020

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RAD50 function is essential for telomere maintenance in Arabidopsis.

31 March 2020

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Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

31 March 2020

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Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere

31 March 2020

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Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process

31 March 2020

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Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events

31 March 2020

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Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break

31 March 2020

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Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

31 March 2020

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Mammalian telomeres end in a large duplex loop

31 March 2020

1 reference

Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM805

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Dimensions publication ID

3 August 2017

1005184288

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