transactivate

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Also found in: Medical.

trans·ac·ti·vate

 (trăns-ăk′tə-vāt′, trănz-)
tr.v. trans·ac·ti·vat·ed, trans·ac·ti·vat·ing, trans·ac·ti·vates
To stimulate the transcription of (a gene in a host cell) by binding to DNA. Genes can be transactivated naturally by a virus or cellular protein or artificially by the insertion of a transactivator gene and segment of DNA into a cell.
trans′ac·ti·va′tion n.
trans·ac′ti·va′tor n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Tang et al., "miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-[kappa]B in high-grade serous ovarian carcinoma," Cell Death and Differentiation, vol.
The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease
Suchy, "Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor," The Journal of Biological Chemistry, vol.
New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications
EGFR is a single transmembrane protein that possesses intrinsic tyrosine kinase activity, which can be directly activated or transactivated in response to a variety of stimuli (Gschwind et al.
Src-mediated EGF receptor activation regulates ozone-induced interleukin 8 expression in human bronchial epithelial cells
Kullak-Ublick, "The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4[alpha] and suppressed by bile acids," Molecular Pharmacology, vol.
Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats
Longer variants containing an Nterminal transactivation domain have been identified as transactivated p63, whereas shorter isoforms that lack the transactivation domain have been designated as p40 (ANp63).
An Immunohistochemical Analysis of a Newly Developed, Mouse Monoclonal p40 (BC28) Antibody in Lung, Bladder, Skin, Breast, Prostate, and Head and Neck Cancers
The above studies have demonstrated the antifibrotic and antiproinflammatory activity of TQ on LX2, a fully transactivated human HSC cell line and fully activated primary rat HSCs.
Anti-fibrotic effect of thymoquinone on hepatic stellate cells
The CXCR4 gene can further be transactivated by the activation of hypoxia-inducible factor- (HIF-) 1[alpha], arising either from loss of the von-Hippel-Lindau tumor suppressor (VHL) or due to the hypoxic conditions observed frequently in tumor tissues [54].
Chemokines in cancer development and progression and their potential as targeting molecules for cancer treatment
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