tacrine

Related to tacrine: Rivastigmine, Galantamine, Metrifonate

tac·rine

(tăk′rēn, -rĭn)

A drug, C₁₃H₁₄N₂, used in its hydrochloride form to treat memory loss and other cognitive deficits in people with Alzheimer's disease.

[t(etrahydro)- (tetra- + hydro-) + acr(id)ine.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

tacrine

(ˈtækriːn)

(Pharmacology) pharmacol a drug prescribed to patients of Alzheimer's disease

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

Translations

tacrine

n tacrina

References in periodicals archive ?

* Tacrine (Cognex[R]): Unlike donepezil, rivastigmine and galantamine, this drug prevents breakdown of acetylcholine in the body as well as the brain, which may help with earlier- and mid-stage Alzheimer cases.

Deeply affected: as the nation ages, Alzheimer's will strike more people close to us

Both lack the potential liver toxicity and four-times-a-day dosing that have virtually eliminated tacrine's use.

Behavorial Symptoms Improve by Adding an SSRI

Tacrine (Cognex) is used to prevent the breakdown of ACh and, thereby, improve cognitive function in AD patients.[20] Donepezil (Aricept) is another drug used to preserve available amounts of ACh, which facilitates cognitive functions.[20] These benefits support the notion that a deficiency in ACh causes the cognitive problems related to AD.

Neurobiological Bases for Alzheimer's Disease

Tacrine (Cognex) and donepezil (Aricept) are the only two acetylcholinesterase inhibitors available in the United States.

Donepezil for Alzheimer's disease

Keywords: Alzheimer's disease, clinical trials, meta-analysis, systematic review, tacrine

Methodology, results and quality of clinical trials of tacrine in the treatment of Alzheimer's disease: a systematic review of the literature

Since the drug's approval, the need for weekly liver function tests has likely made some physicians reluctant to prescribe Cognex (tacrine hydrochloride) for their patients with Alzheimer's disease.

"Medicare risk:" who's really at rick?

Farlow, Cholinesterase Inhibition for Alzheimer Disease: A Meta-Analysis of the Tacrine Trials, J.

Synthesis of Bromo Phenyl Piperidine Derivatives and the Study of their Effects on Neurotransmitters and Strong Compatibility with Alpha Amylase Enzyme

CYP1A2 plays an important role in the metabolism of several clinically used drugs, including theophylline, clozapine and tacrine, and foodborne procarcinogens such as polycyclic aromatic hydrocarbons or imidazoquinoline derivatives (Faber et al.

Investigation of cytochrome P450 inhibitory properties of maslinic acid, a bioactive compound from Olea europaea L., and its structure-activity relationship

Compound Docking scores (kcal x [mol.sup.-1]) Trichlorfon -5.7 Echothiophate -5.9 Isoflurophate -5.9 Pyridostigmine -6.3 Neostigmine -7.5 Parathion -7.6 Rivastigmine -7.9 Tacrine -8.8 Ladostigil -9.1 Physostigmine -9.1 Huperzine A -9.7 Ungeremine -10 Galantamine -10.2 Donepezil -12.1 2 -9.1 3 -9.4 6 -7.8 7 -5.7 8 -7.6 9 -7.9 14 -10

Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents

A new drug called tacrine (which is sold under the brand name Cognex) slows deterioration, but only modestly, only in some patients, and only for six months or so.

Alzheimer's in the family

One of the most innovative and often discussed pharmaceutical introductions in 1993 was tacrine HCI, Parke-Davis' treatment for mild to modedrate dementia resulting from Alzheimer's disease.

APhA reviews new drugs

Huperzine A, like the drug tacrine (THA), prevents acetylcholinesterase from breaking down this essential chemical, thus raising levels of acetylcholine in the brain and improving memory.