A presentation on the additional analysis results from clinical phase II study of dual
orexin receptor
He oversaw clinical development of gene knockdown technology to evaluate novel antisense delivery approaches, worked on multiple teams that designed PET tracers to image therapeutic targets in the brain, and initiated a translational electroencephalogram sleep research lab that was instrumental in the discovery, development, and regulatory approval of Belsomra (suvorexant), a first-in-class
orexin receptor antagonist, in both the United States and Japan.
Optinose announced that it has entered into a license agreement with Inexia whereby Inexia has obtained certain rights that will enable the use of Optinose's exhalation delivery systems, or EDS, and other intellectual property in their effort to discover and develop novel therapies based on positive modulators of
Orexin OX1 and OX2 for neurological diseases.
However, the new class of drugs called dual
orexin receptor antagonists (DORAs) more selectively targeted the brain's sleep or wake pathways, which gives them safety advantages over benzodiazepines, said researchers from the Kagoshima University.
Orexin in patients with alcohol dependence treated for relapse prevention: A pilot study.
It also includes
orexin neurons in the lateral hypothalamic area (LHA) and histaminergic neurons in the tuberomammillary nucleus (TMN).
Orexin is a neuropeptide released from the lateral hypothalamus to adjust food intake, sleep state, autonomous nervous system activity and basal metabolic rate.
The LH has 3 distinct populations of neurons: neurons that produce
orexin, neurons that produce melanin-concentrating hormone (MCH), and neurons containing isoform 65 of glutamic acid decarboxylase (GAD65), named "GAD65 neurons."