folinic acid

Two different chemotherapeutic protocols were applied: (a) 5-fluorouracil (5-FU) and calcium folinate (six cycles of monthly bolus intravenous calcium folinate 20 mg/[m.sup.2]/day, days 1-5 and 5-FU 400-425 mg/[m.sup.2]/day, days 1-5); and (b) capecitabine regimen: orally at a dosage of 1000 mg/[m.sup.2] twice daily on days 1-14 of a three-week period.

Group 1 received neoadjuvant multi-agent chemotherapy, which consists of Docetaxel 75 mg/[m.sup.2] on day one + 5-Phthoruracil 500 mg/[m.sup.2] on days two-five + Calcium Folinate 50 mg/[m.sup.2] on days two-five.

Three to five drugs were administered for chemoembolization including fluorouracil (500-1000 mg), calcium folinate (200-300 mg), pirarubicin hydrochloride (30-50 mg), oxaliplatin (100-150 mg), mitomycin (8-14 mg), and hydroxycamptothecin (10-14 mg).

Distribution of first-line chemotherapy agents Most used chemotherapy agents n (%) Platinum+ Fluorouracil 14 (22.8) Paclitaxel 10 (16.4) Etoposide 6 (9.8) Gemcitabine 7 (11.4) Docetaxel 6 (9.8) Vinorelbine 2 (3.3) Single agent fluorouracil 7 (11.5) Single agent gemcitabine 7 (11.5) FOLFIRI/B * 1 (1.6) Single agent platinum 1 (1.6) Single agent capecitabine 1 (1.6) * FOLFIRI\B: Fluorouracil, calcium folinate, irinotecan, bevacizumab TABLE 2.

In patients in whom 5-MTHF and/ or methyl B12 are too stimulating (as in COMT/MAO SNP defects), substitution with folinic acid (calcium folinate) and hydroxo-B12 can be made.

Peripheral venous adjuvant chemotherapy was conducted for 36 cases (5% glucose injection 250 ml plus calcium folinate 300 mg intravenous drip d1-5; 0.9% sodium chloride injection 500 ml plus 5-Fu 500-750 mg intravenous drip d1-5) and the operation was conducted at 4-7 dayafter the completion of chemotherapy.

For this problem, the patient has consulted a rheumatologist who has reached the diagnosis of rheumatoid arthritis with the additional information gathered by laboratory testing and X-rays (data not available) and a pharmacological treatment was started with methotrexate, calcium folinate, methylprednisolone, indometacin, lansoprazole, and sucralfate.

20 mg in 7 ml (1's) Calcium Folinate Tablet 15 mg 10 tab/box Liquid Tnj.