exonuclease


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ex·o·nu·cle·ase

 (ĕk′sō-no͞o′klē-ās′, -āz′, -nyo͞o′-)
n.
Any of a group of enzymes that catalyze the hydrolysis of single nucleotides from the end of a DNA or RNA chain.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

exonuclease

(ˌɛksəʊˈnjuːklɪˌeɪz)
n
(Biochemistry) an enzyme that is capable of detaching the terminal nucleotide from a nucleic acid chain. Compare endonuclease
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.exonuclease - a nuclease that releases one nucleotide at a time (serially) beginning at one of a nucleic acid
nuclease - general term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
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References in periodicals archive ?
DNA polymerase s and 8 exonuclease domain mutations in endometrial cancer.
The emerging genomic landscape of endometrial cancer
The DNA polymerase used in pyrosequencing is the Klenow fragment (bacterial exonuclease I with the exonuclease function deleted).
Fundamentals of pyrosequencing
The genomic DNA is then converted to single-stranded targets by using multiplex polymerase chain reaction (PCR) amplification and exonuclease digestion.
Respiratory roundup: what type of cystic fibrosis testing platform is right for your laboratory?
The probe is partially degraded by the polymerase's exonuclease activity in a template-specific reaction, and the product triggers the cleavage of a universal fluorogenic probe.
I see the light! And I see it again and again!
PCR amplifications were performed by using Ex Taq DNA polymerase (Takara Biomcdicals, Shiga, Japan), which has 3' [right arrow] 5' exonuclease activity.
Phylogenetic analysis of West Nile virus, Nuevo Leon State, Mexico
Both pathways can occur in parallel, because Taq polymerases are known to possess different levels of exonuclease activity (22) and may dissociate hairpin structures with only partial digestion of the 5' terminus (23).
Mediator probe PCR: a novel approach for detection of real-time PCR based on label-free primary probes and standardized secondary universal fluorogenic reporters
Mismatch repair is a complex process that depends on MMR proteins and multiple proteins that interact directly with DNA (single-stranded DNA-binding protein; exonucleases I, VII, and X; RecJ exonuclease; DNA helicase II; DNA polymerase III; and DNA ligase).
Microsatellite instability and colorectal cancer
This probe contains a 2-kb EcoRI insert corresponding to a central region of SGI1, comprising parts of S023 and S024 open reading frames (ORFs), which code for putative helicase and exonuclease proteins (6).
Variant Salmonella genomic island 1 antibiotic resistance gene cluster in Salmonella enterica serovar Albany. (Research)
It is a family-A DNA polymerase, with both DNA polymerase activity and exonuclease proofreading activity.
Mitochondrial disorders of DNA polymerase [gamma] dysfunction: from anatomic to molecular pathology diagnosis
PCR products were purified with exonuclease I (New England Biolabs) and shrimp alkaline phosphatase (USB/Affymetrix) according to the manufacturers' instructions.
Biotinylated probe isolation of targeted gene region improves detection of T790M epidermal growth factor receptor mutation via peptide nucleic acid-enriched real-time PCR
by using a real-time, 5' exonuclease (TaqMan) assay, based on a well-characterized polymerase chain reaction (PCR) assay that targets a highly-conserved 223-bp region of a gene (bcsp31) encoding a 31-kDa immunogenic B.
Human neurobrucellosis with intracerebral granuloma caused by a marine mammal Brucella spp. (Dispatches)
Lipid bilayers are formed at the top of the wells and nanopore constructs (a processive exonuclease enzyme combined with an a-hemolysin nanopore containing an adapter molecule, cyclodextrin) are added to the chip to sit within the lipid bilayers, forming a single hole in the bilayer.
Analytical ancestry: evolution of the array in analysis

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