clinical trial

(redirected from Randomized trial)
Also found in: Thesaurus, Medical, Encyclopedia.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.clinical trial - a rigorously controlled test of a new drug or a new invasive medical device on human subjects; in the United States it is conducted under the direction of the FDA before being made available for general clinical use
clinical test
trial, run, test - the act of testing something; "in the experimental trials the amount of carbon was measured separately"; "he called each flip of the coin a new trial"
phase I, phase I clinical trial - a clinical trial on a few persons to determine the safety of a new drug or invasive medical device; for drugs, dosage or toxicity limits should be obtained
phase II, phase II clinical trial - a clinical trial on more persons than in phase I; intended to evaluate the efficacy of a treatment for the condition it is intended to treat; possible side effects are monitored
phase III, phase III clinical trial - a large clinical trial of a treatment or drug that in phase I and phase II has been shown to be efficacious with tolerable side effects; after successful conclusion of these clinical trials it will receive formal approval from the FDA
phase IV, phase IV clinical trial - sometimes the FDA approves a drug for general use but requires the manufacturer to continue to monitor its effects; during this phase the drug may be tried on slightly different patient populations than those studied in earlier trials
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Mentioned in ?
References in periodicals archive ?
The study is a randomized trial with safety and efficacy endpoints for FDA PMA Class III submission.
United Health Products completes human trial study for HemoStyp
"Our large, long-term randomized trial shows that fish oil supplements do not reduce the risk of cardiovascular events in patients with diabetes," said principal investigator Louise Bowman of the University of Oxford.
Fish oil supplements don't ward off heart disease: study
The Cluster Randomized Trial of PSA Testing for Prostate Cancer was conducted at 573 primary care centres in the UK and targeted men aged 50-69 years, who were followed up for 10 years.
Once-off PSA screening does not reduce deaths from prostate cancer
Findings from a randomized trial involving children with autism spectrum disorder (ASD) revealed improvement in symptoms of the disorder among those who received vitamin D3 supplementation.
Autistic children benefit from vitamin D3
But information on the efficacy of more aggressive treatment was lacking until a small, randomized trial found that revascularization of the leg arteries enabled patients to walk farther without discomfort, and was far more effective than conservative therapy at improving quality of life at one year.
LEG ARTERY REVASCULARIZATION MAKES WALKING EASIER
This randomized trial was well-designed and included a variety of treatment centers (university and general hospitals) with interventions performed by experienced surgeons (all of whom had performed at least 20 sling surgeries) and physiotherapists educated specifically in pelvic floor physiotherapy.
Pelvic floor dysfunction
Furthermore, in a recent randomized trial carried out with adolescent competitive swimmers, vitamin C halved the duration of colds in males, although the vitamin had no effect on females.
Vitamin C halves incidence of common cold
A randomized trial by Sathya and colleagues compared the efficacy of an iridium implant plus EBRT versus EBRT alone in patients with T2/T3 disease.[sup.13] The 104 patients (40% cT3) were randomized into 2 groups: (1) 51 received iridium implant of 35 Gy delivered to the prostate over 48 hours plus 40 Gy EBRT delivered at 2 Gy/fraction over 4 weeks and (2) 54 patients were randomized to EBRT alone of 66 Gy in 33 fractions.
The management of high-risk, locally advanced, prostate cancer radiation therapy
SAN DIEGO - Gynecologic surgery patients at the highest risk for postoperative complications who wore an abdominopelvic compression binder for 24 hours after surgery had significantly improved ambulation compared with those who did not wear the binder, results from a randomized trial showed.
Binder improves ambulation after surgery
have reported several studies suggesting that folate is associated with small increases in arsenic methylation, including a randomized trial with folate supplements (Gamble et al.
Relationship of creatinine and nutrition with arsenic metabolism: smith et al. respond

Dictionary browser ?
Full browser ?