A sequence polymorphism in
MSTN predicts sprinting ability and racing stamina in thoroughbred horses.
There are several ways to inhibit
MSTN, such as Folistatin (FS) that is responsible for inhibition by extracellular binding (8,14,18), or by other inhibitors such as follistatin-related gene (FLRG), differentiation and growth factor associated with serum protein 1 (GASP-1) and associated adeno virus (AAV) (3,8,24).
A, Overall proteolysis in C2C12 cells incubated with myostatin (
MSTN) (100 ng/mL) after 2, 4, and 8 h.
Key words: Sansui duck,
MSTN, SNPs, slaughter traits, myostatin.
Myostatin (
MSTN; also known as GDF-8) is a member of the TGF-[beta] superfamily, and functions as a negative regulator of skeletal muscle growth in mammals (Lee, 2004; Kollias and McDermott, 2008).
Myostatin (
MSTN) which also called as 8 growth and differentiation factor involved in beta conversion growing groups to change factors that play a role in reducing the growth in mammals as skeletal muscle Inhibitiory.Comparative analysis between existing Myostatinprotein shows a high degree of sequence conservation between species of sheep a single nucleotide polymorphism (SNP) in the untranslatable region 3 UTR) as a cause muscle hypertrophy in myostatin gene to chromosome 2 (OAR2)in European races have been detected which could be used in breeding programs .
However molecular basis of this phenomenon was not recognized until identification of myostatin (
MSTN) also known as growth differentiation factor--8 (GDF-8) expressed predominantly in skeletal muscles and to a lesser extent in adipose tissue and heart (29), (30).
Outra explicacao de alguns estudos seria a atuacao da miostatina (
MSTN) nas respostas hipertroficas.
Nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) equivalents were analyzed by a quantitative real-time PCR that targeted an 88-bp fragment of the chromosomal myostatin (
MSTN) gene locus and an 85-bp fragment of the mitochondrial genome (Mt: 15195-15279).