fosamprenavir

Resistant virus may gain the upper hand after a switch to Isentress but may remain under control with continued Kaletra therapy, or continued therapy with another PI boosted by Norvir (ritonavir), such as Aptivus (tipranavir), Invirase (saquinavir), Lexiva (fosamprenavir).

Vertex said it sold the royalty stream from Lexiva and Agenerase, which it licensed to Glaxo, to strengthen its financial position and invest in other programs, particularly its hepatitis C drug programs.

Vertex co-discovered the HIV protease inhibitor, Lexiva, with GlaxoSmithKline.

GlaxoSmithKline was also in focus as three of its drugs, Epzicom, Combivir and Lexiva were included in the approved treatment guidelines of the International Aids Society-USA for initial antiretroviral therapy.

On April 29, 2005 GlaxoSmithKline announced that a drug-interaction trial of Lexiva (fosamprenavir) with Nexium (esomeprazole, a proton-pump inhibitor, often used to reduce stomach acidity for relief of reflux, the unwanted flow of stomach acid into the esophagus), had found no reduction in the in the blood level of amprenavir.

The four new anti-HIV drugs that came out in 2003 are Fuzeon, part of a new class of drugs called entry inhibitors or fusion inhibitors; the protease inhibitors Reyataz and Lexiva; and the reverse transcriptase inhibitor Emtriva.

Vertex co-promotes the new HIV protease inhibitor Lexiva with GlaxoSmithKline.

The PIs were Agen-erase or Lexiva (amprenavir or fosamprenavir).

* Scores for these new drugs are preliminary, and these drugs do not appear in the original table.(2) [dagger] Lexiva (fosamprenavir) should penetrate CSF similarly to Agenerase (amprenavir).

Hoffman-LaRoche developed an "improved" version of saquinavir (Fortovase) and GlaxoSmithKline developed fosamprenavir (Lexiva) to replace amprenavir (Agenerase).

Food and Drug Administration approved the protease inhibitor Lexiva (generic name fosamprenavir, also called 908).

- This study involved people from six trials who took Ziagen/Epivir with Sustiva, Reyataz/Norvir, Kaletra (lopinavir/Norvir), or Lexiva (fosamprenavir)/Norvir.