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Review
. 2010 Oct;5(5):421-6.
doi: 10.1007/s11739-010-0385-6. Epub 2010 May 1.

Challenging the superiority of amiodarone for rate control in Wolff-Parkinson-White and atrial fibrillation

Sharis M Simonian  1 , Shahram Lotfipour, Christopher Wall, Mark I Langdorf
Affiliations
Free article
Review

Challenging the superiority of amiodarone for rate control in Wolff-Parkinson-White and atrial fibrillation

Sharis M Simonian et al. Intern Emerg Med. 2010 Oct.
Free article

Abstract

The objective of this review is to explore and challenge the superiority of amiodarone for rate control in Wolff-Parkinson-White syndrome and concomitant atrial fibrillation (WPW-AF). The current recommendation for pharmacological treatment of this condition is amiodarone. A review of the past 25 years of literature finds several studies that identify a small risk of ventricular fibrillation secondary to amiodarone administration for rate control in WPW-AF. Additionally, the literature supports the safe and effective use of procainamide for rate control in WPW-AF. This review concludes that amiodarone is not superior to procainamide in rate control for WPW-AF, and may be dangerous.

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