Some other features favoring dVIN include prominent parakeratosis, a thickened epidermis with elongated and branching
rete ridges, abnormal keratinocytes with squamous whorls or keratin pearls, and strong continuous p53 staining of the basal layer.
The overlying epithelium exhibits hyperplasia and has elongated
rete ridges suggesting the histological diagnosis of fibroepithelial hyperplasia
VX demonstrates a pathognomonic histological profile consisting of abundant, lipoid-rich macrophages with foam cytoplasm between the elongated uniform depth
rete ridges. These cells are characterized by PAS-positive, diastase-resistant granules in their cytoplasm and display positive immunoreaction for the monocyte-macrophage markers CD68 and cathepsin B [2-7, 13, 23].
Histologically, lymphangiomas are characterized by dilated lymphatic vessels present in the papillary dermis, positivity of the lymphatic channels to the lymphatic endothelial marker D2-40, atrophy of the overlying epidermis, and elongation of the
rete ridges [3, 9].
The cystic epithelium showed areas of hyperplasia and broad bulbous
rete ridges (Figure 4) along with areas of hypergranulosis.
of Cases Percentage Hyperkeratosis 49 98% Atrophy 2 4% Parakeratosis 2 4% Hypergranulosis 43 86% Acanthosis 44 88% Hyperplasia 2 8% Saw toothing of
rete ridges 28 56% Liquefactive degeneration 34 68% of basal cell Max Joseph space 2 4% Colloid bodies 2 4% Table 11(b).
Histologically, there is a thin (6 to 8 cells thick) epithelial lining, lacking
rete ridges, which results in a separation or clefting artifact from the fibrous stroma of the cyst wall.
The thickened oral mucosa extends upward, away from the underlying connective tissue with the lesional
rete ridges at the same level as adjacent normal
rete ridges.
Histopathological report of the tongue lesion revealed hyperkeratosis with flattened
rete ridges. There was no evidence of malignancy.
In all cases histopathology revealed fibropapillomatosis with acanthosis, hyperkeratosis and down-growth of
rete ridges. The virus appears to infect the basal cells of the epithelium, causing hyperplasia with hydropic ballooning of their cytoplasms, large eosinophilic keratohyaline granules and vesicular nuclei.
Sixty-two patients developed dermatologist-diagnosed psoriasis marked by the classic histologic features, including epidermal hyperplasia, parakeratosis, agranulosis, elongated
rete ridges, and dilated dermal capillaries.
The epidermis is attached to the dermis by deep, finger-like projections of epidermal tissue called
rete ridges or rete pegs.
Histologically, the cellular components include lentiginous junctional melanocytic proliferation, with lateral fusion of nests and shouldering, and epidermal hyperplasia with elongation of the
rete ridges. The stromal reaction involves fibrosis (concentric eosinophilic, lamellar) and inflammation.
Moreover, a detailed skin biopsy report, obtained via standard pathology diagnostics services, revealed fattening of the dermal papillae
rete ridges, perivascular, perifollicular lymphocytic infltrate, and clumping of collagen fbers.
A surgical biopsy taken from his perianal lesions revealed pseudo-epitheliomatous hyperplasia with irregular elongation of
rete ridges and an inflammatory infiltrate dominated by plasma cells in hematoxylin-eosin staining [Figure 1]c and [Figure 1]d.
