LONDON (Alliance News) - Roche Holding AG on Tuesday announced accelerated US approval for its cancer drug as well as positive results from its phase two
lupus nephritis study.
Clinical usefulness of a prognostic score in histological analysis of renal biopsy in patients with
lupus nephritis. J Rheumatol 2009;36:2218-23.
Causes and predictors of mortality in biopsy-proven
lupus nephritis: the Sarawak experience.
Objective: To determine the value of serial renal biopsies in detecting histological changes in patients with
lupus nephritis with APL antibodies.
Both male and female patients with clinical suspicion of
lupus nephritis having serum ANA and Anti-ds DNA level investigations were included.
Electronic searches were performed using the PubMed, Google Scholar, Embase, and Cochrane trial register databases with the keywords "
lupus nephritis" and "pathology", without restriction on settings or language.
In female patients, the most common type was
lupus nephritis (49.6%) followed by membranous nephropathy and diabetic nephropathy (9.9% each).
Lupus Nephritis (LN) occurs in approximately half of SLE patients.
The first episode occurred with biopsy findings consistent with
lupus nephritis (LN) class V (membranous) without clinical evidences of systemic lupus erythematosus (SLE), and the second episode occurred with pathologic findings of a nonimmune complex podocytopathy on the repeat kidney biopsy, subsequently with positive serologic evidences of SLE.
Of note, ANCA is detected in approximately 15-20% of patients with SLE [1-4] and in 37% cases of
lupus nephritis (LN) [2].
The decision was made to admit the patient for treatment of suspected community-acquired pneumonia (CAP), new-onset nephrotic syndrome likely secondary to
lupus nephritis, and an active SLE flare associated with pancytopenia, malar rash, oral ulcers, and lymphadenopathy.
*
Lupus Nephritis constituted 100% of the secondary glomerular lesions (2 cases) and was serologically confirmed and showed Full House IF.
