Enhanced vasculotoxic metal excretion in post-myocardial infarction patients receiving
edetate disodium-based infusion.
It is a patent-protected, novel solution containing minocycline,
edetate (disodium EDTA), and ethyl alcohol, which act to break down bacterial biofilm, eradicate the bacteria, provide anti-clotting properties to maintain patency, and salvage the indwelling central venous catheter.
Chelating agents such as
edetate calcium disodium (EDTA), sodium 2, 3-dimercaptopropane sulfonate (DMPS), and dimercaprol (BAL) have been reported (Table 1) [7-10].
Group A received oral sodium feredetate (iron
edetate) and group B received intramuscular iron sorbitol.
Treatment was started with Ringer's acetate and 5% dextrose given subcutaneously (calculated for 5% dehydration based on body weight), enrofloxacin (15 mg/kg SC q24h; Baytril 10%, Bayer Health Care, Provet AG, Lyssach, Switzerland), itraconazole (10 mg/kg PO q24h; Sporanox, Janssen-Cilag AG, Baar, Switzerland), vitamin B complex (30 mg/kg SC q24h), calcium disodium
edetate (Ca-EDTA) (100 mg/kg SC q12h), and meloxicam (0.5 mg/kg SC q24h; Metacam, Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland).
There are six agents available to treat heavy metal (arsenic, gold, iron, lead, and mercury) intoxication: de-ferasirox (iron), deferoxamine (iron), dimercaprol (arsenic, gold, lead, and mercury),
edetate calcium disodium (lead), penicillamine (copper and mercury), and succimer (lead).
Additional ingredients of the eye drops were benzalkonium chloride (preservative), sodium
edetate, hypromellose, sorbitol, sodium hydroxide, and water.
Currently, chelating agents such as disodium
edetate calcium (EDTA[Na.sub.2]Ca) and sodium dimercaptosuccinate (NaDMS) are commonly used in clinical to treat lead poisoning.
Deaths Resulting from Hypocalcemia after Administration of
Edetate Disodium: 2003-2005.
The FDA alleged that Evers had violated the Federal Food, Drug, and Cosmetic Act (the Act) under misbranding provision by promoting and administering a chelating drug, calcium disodium
edetate (calcium EDTA), an FDA-approved drug for an indication not approved by the agency.
The sodium
edetate preferentially forms more stable complexes with polyvalent cations (e.g.
Propofol is an alkyl phenol (2, 6-diisopropyl phenol) and is formulated as a 1% emulsion containing 10% soybean oil, 2.25% glycerol and 1.2% purified egg phosphatide with disodium
edetate or sodium metabisulphite added as a preservative (2).
Combined therapeutic potential of Meso 2, 3 dimercaptosuccinic acid and calcium disodium
edetate in experimental lead Intoxication in rats.
(104) The doctrine of equivalents dispute centered on whether
edetate, a chemical required by the language of the claims, could reach via equivalence the accused product, which used calcium trisodium DTPA rather than
edetate.
(14) in addition to the active component, propofol, the formulation also contains glycerol 2.25%, egg lecithin 1.2%, and disodium
edetate 0.005%, with sodium hydroxide to adjust pH.
