CBTs are slowly growing and generally benign tumors arising from
chemoreceptor tissues in carotid bifurcation.
Chemoreceptors are assigned the roles of recognizing the concentrations of oxygen in blood and cells.
The cardiovascular response to hypoxia is to increase cardiac output; heart rate increases due to the reflex responses of carotid and aortic
chemoreceptors as well (1).
Facilitating the oxyhemoglobin dissociation shift is an increase in
chemoreceptor control of ventilation brought on by decreased bicarbonate in the cerebrospinal fluid and excretion of bicarbonate by the kidneys (1).
To simulate the prehypertensive SS baroreceptor systemic phenotype of partial baroreceptor impairment (10,13), a chronic bilateral aortic denervation was performed instead of a chronic bilateral carotid sinus denervation, because the destruction of
chemoreceptors during the carotid sinus denervation (22,23) in a species like the rat, which lacks functional aortic body
chemoreceptors (25), causes chronic hypoventilation with consequent chronic systemic hypoxia, which in turn has the chronic effect of lowering blood pressure (23).
The
chemoreceptor trigger zone (CTZ) is a specialised region of the brainstem identified as the site for chemical stimulation of vomiting, and perhaps, nausea.
Indeed additional oxygen would likely decrease the heart rate and blood pressure as well by negating peripheral
chemoreceptor stimulation.
Chemoreceptor cells are responsible for changes in blood pH, oxygen tension, and carbon dioxide content (JOHNSON, 1968; CAPEN, 2007).
As a
chemoreceptor, it is distinct from the carotid sinus, which is a baroreceptor.
Peripheral
chemoreceptor physiology provides this answer.
[15] It is possible that some of the ventilatory response mediated by the muscle afferents was due to an increase in peripheral
chemoreceptor drive.
Certain extra-gastrointestinal stimuli alter body chemistry and may activate the
chemoreceptor trigger zone in the brainstem.
The morphology of spider sensilla
chemoreceptor. Tiss.
Although traditionally used in treatment of psychosis, haloperidol has an effect on dopamine D2 receptors in the
chemoreceptor zone and potentially on cannabinoid 1 (CB1) receptors in the central nervous system.
(91) With respect to cellular environments, the general redox environment and carotid body (CB)
chemoreceptor function have been evaluated by reactive disulphides and other oxidative agents.
