Definitive diagnosis of some of the BFL can be challenging from core needle biopsy (CNB) due to increased
cellularity and complex structures.
Areas with high tumor
cellularity are marked on the reverse side of the slide before removal of the coverslip and application of 2 fluorescently labeled DNA FISH probes, which hybridize to the centromeric and telomeric segments flanking the ALK (2p23) gene.
But in images with high b-values, this effect diminishes and the signal intensity highly depends on
cellularity (25).
Patients who had FLT3-ITD mutations had significantly higher WBC counts, bone marrow blasts and biopsy
cellularity at the time of presentation.
Effects of selenium supply and dietary restriction on maternal and fetal body weight, visceral organ mass,
cellularity estimates, and jejeunal vascularity in pregnant ewe lambs.
Increases in mitotic activity,
cellularity or nuclear atypia in tumors are the predictors that aid in an estimation of recurrences (2).
Caption: Figure 3: Presurgical images of a 53-year old GBM patient show a heterogonous contrast enhancement on the T1 postcontrast image (a), disrupted blood brain barrier and increased vessel density on leakage [[lambda].sup.tr] (b) and [V.sub.p] (c) maps overlaid on the T1-weighted image, and high
cellularity on DWI (d).
[9] first described the histological criteria for atypical bronchopulmonary carcinoid tumors in 1972, namely, increased mitotic activity with 5-10 mitoses per 2 [mm.sup.2] (10 high-power field (HPF)), nuclear pleomorphism, and irregularity with hyperchromatism and prominent nucleoli, areas of increased
cellularity with disorganization, and necrosis.
Pathological examination of the mass was remarkable for a multinodular proliferation of benign fibroblasts with variable
cellularity including hyalinized hypocellular areas (Figures 3(a) and 3(b)).
The subsequent report revealed marked
cellularity and pleomorphism, extensive necrosis, mitosis >5/10BBA, KI67 proliferation index > %50, weak-positivity for p53, and LMS with no detectable lymphovascular invasion.
Histologically, it can show a certain degree of cell mitosis and
cellularity, which can raise suspicion of malignancy, even though they are benign.
Bone marrow biopsy demonstrated reduced
cellularity (10-15%), reduced erythropoiesis, granulopoiesis, and megakaryocytes.
Despite the classical form, many cytological features such as high mitotic activity and increased
cellularity associated with aggressive behavior were described in the literature (4).
