Because depression is estimated to soon become the second leading cause of death due to complications arising from stress and the cardiovascular system, and the adverse side effects of current
monamine oxidase inhibitors and older antidepressants, there is a pressing need to develop more effective treatments.
Major Finding: Scans revealed 43% more
monamine oxidase across all brain regions in women during postpartum days 4-6, compared with those in controls.
Potential subjects were excluded if they had allergies to any of the study medications, had ocular or systemic diseases; had used systemic or ocular antihistamines, vasoconstrictor drugs, decongestants, immunotherapies,
monamine oxidase inhibitors, artificial tears, lid scrubs, mass cell stabilizers, prostaglandins, or ocular nonsteroidal anti-inflammatory drugs within 7 days of study initiation; had used inhaled, ocular, topical, or systemic corticosteroids within 2 weeks or depocorticosteroids within 45 days of study initiation
Modafinil has little effect on the catecholamine, serotonin, histamine, adenosine, and
monamine oxidase B systems.
First-line treatments are sertraline and citalopram; among contraindicated treatments are tricyclic antidepressants and
monamine oxidase inhibitors, which have cardiotoxic side effects, the advisory states.
[beta]-carboline alkaloids increase norepinephrine, dopamine and serotonin levels in several brain regions via inhibition of
monamine reuptake systems (Callaway & Grob 1998; Kleven & Woolverton 1993; Komulainen et al.
Meperidine is uniquely toxic in cases of renal failure and for patients on
monamine oxidase inhibitors.
* Special Considerations: Clarinex-D 24 Hour is contraindicated in patients with narrow-angle glaucoma, urinary retention, severe hypertension, severe coronary disease, and in patients who have taken a
monamine oxidase inhibitor in the previous 14 days.
