cell

Various factors contribute to the hepatic I/R injury, namely the Kupffer cell activation, oxidative stress, and upregulation of proinflammatory cytokine signaling.

Leclercq, "Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet," The FASEB Journal, vol.

Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells. Hepatology, 29: 735-745.

Specific super-paramagnetic iron oxide-based (eg, ferucarbotran [Resovist; Schering, Berlin, Germany]) and manganese-based (ie, mangafodipirtrisodium [Tesla-scan; Nycomed Amersham, Oslo, Norway]) contrast media are targeted at the Kupffer cells and hepatocytes, respectively.

(d) Higher magnification well demonstrates contact HPC I with T-HSC and with Kupffer cells. Scale bar, 0.5 [micro]m, original magnification x20000.

Subsequently, a liver biopsy was performed and showed a mild nonspecific portal lymphocytic inflammatory infiltrate and aggregates of Kupffer cells containing ceroid pigments in the hepatic lobules and perivenular areas.

HAAA is associated with immunological abnormalities mediated by [CD8.sup.+] Kupffer cells [25].

Liver biopsy documented increased iron uptake in the hepatocytes and Kupffer cells (Figure 1).

Chen, "Role of Kupffer cells in acute hemorrhagic necrotizing pancreatitis-associated lung injury of rats," World Journal of Gastroenterology, vol.

Kupffer cells (internal controls) had strong positive immuno labeling (Figure 1H).