The two recent serious cases of
EV71 involved a two-year-old girl and a two-year-old boy who have since been discharged from hospitals in northern Taiwan, bringing the number of infections with serious complications to 28 for 2019 -- higher than the levels recorded during the same period from 2016-2018, the CDC said.
Several large outbreaks of HFMD caused by
EV71 have occurred in the Asia-Pacific region since 1997.
EV71 and CVA10 have also been associated with neurological complications (encephalitis) and death (4, 23).
The
EV71 vaccine, an innovative vaccine developed by Sinovac against hand foot and mouth disease caused by
EV71, was commercialized in China in 2016.
Wang, "Recombinant VP1 protein expressed in Pichia pastoris induces protective immune responses against
EV71 in mice," Biochemical and Biophysical Research Communications, vol.
Human enterovirus 71 (
EV71) belongs to the Enterovirus genus of the family Picornaviridae and causes sporadic outbreaks of HFMD.
The genus Enterovirus (EV), one group of the picornavirus family, has the following species according to the International Committee on Taxonomy of Viruses: EV-A, which contains
EV71 and several Coxsackievirus group A (CVA) viruses; EV-B (Coxsackievirus group B (CVB) viruses, CVA9, echoviruses and few other EV); EV-C (polioviruses (PV) 1-3, several CVA and few other EV); EV-D (EV-D68, EV-D111, EV 70 and EV74); EV-E, EV-F, EV-G, EV-H, EV-J, and the rhinoviruses (HRV-A, HRV-B, HRV-C).
This effective management of the potential public health threat by all walks of groups nationwide, especially health care and disease prevention and control system, brought out the dramatic progress on national efforts that having been made to control kinds of communicable diseases in the last 10 years, including human avian influenza H7N9, hand-foot-mouth disease
EV71, etc.
HFMD is a common infectious disease caused by a group of enteroviruses, including Coxsackievirus A16 (CA16) and Enterovirus 71 (
EV71).
Fecal sample was positive for
EV71 RNA by real-time PCR.
Staff members from these two laboratories were trained in the WHO- and CDC-approved real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay for influenza A(H7N9) detection, and in new testing platforms using rRT-PCR for detection of enterovirus 71 (
EV71), and in multiplex PCR for detection of seven respiratory pathogens.
