The Appalachian League had seven players selected on Day 1 with 28 overall alumni selected over the course of the 2025 MLB Draft. In addition, 12 former Appy players subsequently signed with MLB clubs as undrafted free agents.
2025 Drafted Players
| Round | Pick | Team | Player | Position | School | Appy League Team | Year |
|---|---|---|---|---|---|---|---|
| CB-A | 33 | Boston Red Sox | Marcus Phillips | RHP | Tennessee | Elizabethton River Riders | 2024 |
| 2 | 53 | Tampa Bay Rays | Cooper Flemming | SS | Aliso Niguel HS (Calif.) | Bristol State Liners | 2025 |
| CB-B | 72 | St. Louis Cardinals | Tanner Franklin | RHP | Tennessee | Kingsport Axmen | 2023 |
| 3 | 84 | Texas Rangers | Josh Owens | TWP | Providence Academy (Tenn.) | Elizabethton River Riders | 2025 |
| 3 | 94 | Milwaukee Brewers | Jacob Morrison | RHP | Coastal Carolina | Princeton WhistlePigs | 2022 |
| 3 | 96 | Atlanta Braves | Cody Miller | SS | East Tennessee State | Johnson City Doughboys | 2023 |
| 3 | 100 | Philadelphia Phillies | Cody Bowker | RHP | Vanderbilt | Elizabethton River Riders | 2022 |
| 8 | 240 | St. Louis Cardinals | Ryan Weingartner | SS | Penn State | Elizabethton River Riders | 2023 |
| 8 | 247 | Atlanta Braves | Carter Lovasz | RHP | William & Mary | Elizabethton River Riders | 2022 |
| 9 | 273 | Arizona Diamondbacks | Wallace Clark | SS | Duke | Greeneville Flyboys | 2023 |
| 9 | 284 | New York Yankees | Blake Gillespie | RHP | UNC Charlotte | Bluefield Ridge Runners | 2024 |
| 10 | 296 | San Francisco Giants | Isaiah Barkett | 2B | Stetson | Burlington Sock Puppets | 2023 |
| 10 | 308 | Kansas City Royals | Max Martin | RHP | UC-Irvine | Pulaski River Turtles | 2024 |
| 11 | 343 | New York Mets | Wyatt Vincent | OF | Nixa HS (Mo.) | Pulaski River Turtles | 2025 |
| 13 | 396 | Houston Astros | Aubrey Smith | RHP | UNC Wilmington | Bristol State Liners | 2023 |
| 14 | 412 | Toronto Blue Jays | Noah Palmese | RHP | Webber International | Bristol State Liners | 2024 |
| 14 | 429 | Detroit Tigers | Beau Ankeney | 1B | Loyola Marymount | Greeneville Flyboys | 2022 |
| 14 | 430 | San Diego Padres | Clay Edmondson | RHP | UNC Asheville | Pulaski River Turtles | 2023 |
| 15 | 448 | Boston Red Sox | Skylar King | OF | West Virginia | Elizabethton River Riders | 2023 |
| 16 | 474 | Cincinnati Reds | Maison Martinez | RHP | Florida State | Danville Otterbots | 2024 |
| 16 | 483 | Arizona Diamondbacks | Collin Rothermel | RHP | Jacksonville | Elizabethton River Riders | 2022 |
| 16 | 494 | New York Yankees | Jackson Lovich | SS | Missouri | Pulaski River Turtles | 2023 |
| 17 | 511 | Chicago Cubs | Logan Poteet | C | UNC Charlotte | Kingsport/Tri-State | 2022/2024 |
| 17 | 513 | Arizona Diamondbacks | Joel Sarver | RHP | UNC Charlotte | Danville Otterbots | 2021 |
| 18 | 550 | San Diego Padres | Landry Jurecka | RHP | Queens U of Charlotte | Pulaski River Turtles | 2025 |
| 19 | 556 | Chicago White Sox | Nick Weyrich | RHP | Marshall | Pulaski River Turtles | 2023 |
| 19 | 585 | Los Angeles Dodgers | Anson Aroz | C | Oregon | Johnson City Doughboys | 2022 |
| 20 | 614 | New York Yankees | Bryce Martin-Grudzielanek | SS | Southern California | Bluefield Ridge Runners | 2023 |
* = Did not sign
2025 Undrafted Free Agents
| MLB Team | Player | Position | School | Appy Team | Year |
|---|---|---|---|---|---|
| Toronto Blue Jays | Sam White | 3B | West Virginia | Pulaski | 2023 |
| Los Angeles Angels | Ryland Zaborowski | 1B | Georgia | Pulaski | 2022 |
| Philadelphia Phillies | Jonathan Hogart | OF | Murray State | Greeneville | 2021 |
| Philadelphia Phillies | Bennett Markinson | C | Northwestern | Princeton | 2022 |
| Athletics | Jackson Holmes | RHP | Missouri State | Elizabethton | 2022 |
| Athletics | Owen Carapellotti | C | Georgetown | Elizabethton | 2022 |
| Minnesota Twins | Ian Daugherty | C | Oklahoma State | Greeneville | 2022 |
| New York Mets | John Bay | OF | Austin Peay | Pulaski | 2021 |
| Baltimore Orioles | Isaac Silva | RHP | Murray State | Burlington/Bluefield | 2023/24 |
| Boston Red Sox | Caleb Berry | C | Michigan State | Johnson City | 2023 |
| Los Angeles Angels | Aaron Graeber | OF | Delaware | Bristol | 2022 |
| Milwaukee Brewers | Tanner Perry | RHP | Illinois State | Johnson City | 2023 |
| Milwaukee Brewers | Michael Fowler | RHP | Southern Mississippi | Bristol | 2021 |
| Cincinnati Reds | Henry Hunter | C | Georgia | Kingsport | 2022 |
| Chicago White Sox | Trey Cooper | LHP | Liberty | Burlington | 2022/24 |
| Cleveland Guardians | Wes Burton | RHP | Tulane | Bristol | 2021 |
| Minnesota Twins | Carter Holjes | RHP | Florida Atlantic | Danville | 2021/24 |
| Baltimore Orioles | Zac Lampton | LHP | Florida International | Pulaski | 2022 |
| Baltimore Orioles | Marcos Reynoso | RHP | N/A | Pulaski | 2025 |