Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)

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Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone
+
Differin Acne Face Wash with 5% Benzoyl Peroxide, Daily Deep Cleanser by the makers of Differin Gel, Gentle Skin Care for Acn
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Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone

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Product details

About this product

Top highlights

  • TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
  • CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
  • REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
  • THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne

Top Brand: Differin Differin

Brand insights

85% of ratings are 4+ stars for this brand

100K+ orders for this brand in past 3 months

Customers usually keep items from this brand

Brand summary

From brand and product information, Differin offers dermatology-backed skincare solutions including acne treatments, cleansers, moisturizers, and sunscreens. Their science-driven approach focuses on effective ingredients for comprehensive daily skincare routines.

AI-generated from brand and product info

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin�s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).

Important information

Safety Information

For external use only. Do not use on damaged skin (cuts, abrasions, eczema, sunburn). Do not use if you are allergiv to adapalene or any of the ingredients in this product. If pregnant or breast-feeding, ask a doctor before use. When using this product limit sun exposure, including light from tanning beds, and use sunscreen outdoors. Do not wax to remove hair in areas where the product has been applied. During the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue as directed, unless you get irritation that becomes severe.

Indications

Face

Ingredients

Active Ingredients: Adapalene (0.1%)(Retinoid). Purpose: Acne Treatment, Read Consumer Information Leaflet. Inactive Ingredients: Carbomer 940, Edetate Disodium, Methylparaben, Poloxamer 182, Propylene Glycol, Purified Water and Sodium Hydroxide, May Contain Hydrochloric Acid to Adjust pH.

Directions

Adults and children 12 years of age and older:- Use once daily- Clean the skin gently and pat dry before applying the product- Cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face.- Do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation.

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From the brand

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From the manufacturer

Differin Gel Allure

Face

The video showcases the product in use.The video guides you through product setup.The video compares multiple products.The video shows the product being unpacked.

How to use Differin Gel

Merchant Video
Choose your acne treatment
  • Differin Gel is formulated with Adapalene Retinoid, which works deep into pores in 5 minutes. When consistently applied to the full face, you may start to see results in as little as 1 week with best results after 12 weeks.

  • Differin Gel includes Adapalene an ingredient shown to have improved tolerability resulting in less redness and skin irritation. Apply once daily to dry skin after cleansing. Stop use and consult a dermatologist if irritation becomes severe.

  • Use once daily (AM or PM). Clean skin gently and pat dry before applying. Cover the entire face with a thin layer. Do not use more than once a day. Applying more than directed will not provide faster or better results and may worsen skin irritation.

  • Moisturizing is essential in supporting the skin barrier when using Differin Gel and can help to combat excessive dryness or irritation. Apply Differin Gel to clean, dry skin then follow with non-comedogenic moisturizer and SPF in the AM.

  • Acne may appear to worsen within the first few weeks of use as Differin Gel accelerates skin cell turnover. Continue treatment as directed; symptoms should subside between weeks 2-4. If severe irritation occurs stop use and consult dermatologist.

Shop Skincare Routine

5% BPO Daily Cleanser

10% BPO Acne Cleanser

Dark Spot Corrector Serum

0.1% Adapalene Gel

Oil Absorbing Moisturizer

Customer Reviews
4.5 out of 5 stars 13,513
4.6 out of 5 stars 1,786
4.1 out of 5 stars 2,873
4.5 out of 5 stars 70,888
4.4 out of 5 stars 7,422
Price
$9.79 $10.97 $18.11 $13.48 $17.29
Use for
Deep Cleaning Pores Quickly clearing acne Reducing post-acne marks Clearing, preventing acne Hydrating sun protection
Key ingredient
5% Benzoyl Peroxide 10% Benzoyl Peroxide 4% Niacinamide 0.1% Adapalene 5% Octisalate 7% Octocrylene
Target areas
Face & Body 10% Benzoyl Peroxide Face Face Face
Skin type
All Skin Types Acne-prone All Skin Types Acne-prone Oily Skin
Shop Differin products
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Customers say

Customers find the acne treatment gel effective, with visible results within a week, and appreciate its good quality and value for money. The product improves skin appearance by evening out tone and creating a dewy, luminous complexion, while making it smoother and softer. Customers disagree on whether it's suitable for sensitive skin, and while some report it lasts a long time, others experience flaking.
AI Generated from the text of customer reviews

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228 customers mention effectiveness, 187 positive, 41 negative
Customers find that the acne treatment gel works wonders, with visible results, and one customer mentions it performs better than benzoyl peroxide.AI Generated from the text of customer reviews
This does help with controlling breakouts and treating acne. Works great, I use this during the day and at night I switch to geologie pm for night.Read more
...This is a great product that works well for what is intended to do, but you will need to have it be just one part of an overall skincare routine...Read more
...🧴 Gentle Yet Effective: I was worried a retinoid gel would dry out my skin, but this formula feels lightweight and absorbs quickly....Read more
This product is very effective. It was recommended by our pediatrician and we have it for both our pre teens. Apply carefully!!...Read more
100 customers mention quality, 93 positive, 7 negative
Customers find the acne treatment gel to be of good quality, with one customer noting its effectiveness when used consistently.AI Generated from the text of customer reviews
Great product that works amazingly which has shown great results. I rarely have acne now and the product lasts long and it doesn’t take much to use....Read more
My son told me that it works well for him. A good product.Read more
This is an excellent product and I love this type of dispenser....Read more
Amazing product 🤩Read more
68 customers mention skin appearance, 55 positive, 13 negative
Customers report significant improvements in their skin appearance, noting a dewy and luminous complexion, even skin tone, and clearer skin.AI Generated from the text of customer reviews
...I’ll forever buy this product! Thank you for my clear skin!!!!!Read more
...They’ve definitely seen clearer skin since starting to use it!Read more
...about a month ago for closed comedones (blackheads) , and my skin hasn't looked better....Read more
It really evened out my skin tone and helped with breakouts!Read more
52 customers mention value for money, 40 positive, 12 negative
Customers find the acne treatment gel to be worth the price, with one customer noting it's effective without being overly harsh or expensive.AI Generated from the text of customer reviews
...It can take between 3-6 months to see results. But it’s so worth it and it works my arms are smoother and now it’s in the phase of just getting rid...Read more
...📆 Great Value: A 90‑day supply is generous and makes it easy to stay consistent, which is key with acne treatments....Read more
...I felt like it took about a month to see a difference. It’s inexpensive and I like that it’s sold with a pump in a bigger size.Read more
...Disappointing but this stuff is pricey so I try to use the product and find the pump does not work. Nothing comes out....Read more
31 customers mention skin texture, 25 positive, 6 negative
Customers report that the acne treatment gel improves skin texture, making it smoother and softer, with one customer noting that it absorbs well without causing irritation or dryness.AI Generated from the text of customer reviews
...I tested a tube of this first. I really liked the texture and gentleness of this....Read more
Makes my skin very soft and lightweight with great absorbency. Unfortunately it’s to strong for my sensitive skinRead more
...It’s made my face noticeably clearer and has significantly improved my skin texture over time....Read more
This gel has been effective for helping improve breakouts and overall skin texture....Read more
269 customers mention drying, 179 positive, 90 negative
Customers have mixed experiences with the acne treatment gel, with some finding it amazing for their skin and helping keep it clear, while others report that it can be drying.AI Generated from the text of customer reviews
This has saved my skin! My acne has gotten so much better I recommend this to everyone.Read more
...skin, I would recommend you use this for big pimples only, as it is very drying. Also wouldn't recommend for small, scattered acne....Read more
As of yet, the best acne treatment ever.Read more
...Best investment and savior for your face! It cleared my acne and helped with any hyperpigmentation I had as well....Read more
72 customers mention skin sensitivity, 28 positive, 44 negative
Customers have mixed experiences with how the acne treatment affects their skin, with some finding it gentle and non-irritating, while others report that it can really irritate their skin and causes burning sensations.AI Generated from the text of customer reviews
...Cons: - extremely drying and not for sensitive skin. I used this product once a week and it made my face flake....Read more
...🧴 Gentle Yet Effective: I was worried a retinoid gel would dry out my skin, but this formula feels lightweight and absorbs quickly....Read more
Made my skin burn and turn red pretty badly. It irritated my healed acne so much they reopened and are now super angry and red and they hurt....Read more
I have a chemical burn under my eyesRead more
37 customers mention duration, 18 positive, 19 negative
Customers have mixed experiences with how long the acne treatment gel lasts, with some reporting it lasts a long time while others mention it peels over several days and causes flaking around the mouth.AI Generated from the text of customer reviews
...My skin didn't respond well to the product. My skin started to peel. But my face is very sensitive. I don't like trying new products to often.Read more
...One pump is enough for the whole face so this product lasts for ages. Definitely recommend for oily, comination, or normal skin....Read more
...your mouth, nose, chin, and eye area as it can be very harsh and cause peeling, dryness, itching, and redness....Read more
...three times a week per my Dermatologist’s recommendation so it lasts a long time....Read more

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Top reviews from the United States

  • 5 out of 5 stars
    Verified Purchase

    Reliable Long-Term Acne Treatment That Works With Consistent Use

    Reviewed in the United States on January 26, 2026

    I’ve been using Differin Gel for years, and it’s a staple in my routine. This is one of the few acne treatments I consistently repurchase because it actually helps when used correctly and patiently.

    Differin works by regulating skin cell turnover, so results are gradual rather than overnight. If you’re starting for the first time or restarting after a long break, it’s normal to experience an initial breakout phase as your skin adjusts. In my experience, this settles with continued, consistent use, and overall breakouts become less frequent and less severe over time.

    The gel itself is lightweight, fragrance-free, and easy to incorporate into an evening routine. A thin layer goes a long way. I also find it’s best used as part of a simple, gentle skincare routine, especially since this type of product can make skin feel more sensitive at first.

    I keep this on hand at all times and reorder it regularly. One downside is that the price fluctuates on Amazon, so I usually wait to restock when it drops.

    Overall, this is a solid option for anyone looking for a long-term acne treatment rather than a quick fix. It takes patience, but it’s been very reliable for me over the years.

    Pros:

    - Effective with consistent, long-term use

    - Lightweight, non-greasy gel

    - Fragrance-free and easy to layer into a routine

    -One pump lasts a long time

    Cons:

    - Adjustment period can cause temporary breakouts

    - Skin may feel more sensitive at first

    - Price fluctuates

    26 people found this helpful
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  • 5 out of 5 stars
    Verified Purchase

    Great and Effective Acne Gel

    Reviewed in the United States on April 18, 2026

    This acne gel has worked really well for my sons. After using it consistently, they noticed a visible improvement in breakouts and redness. It helps dry out pimples quickly without being too harsh on their skin. The gel goes on smoothly, absorbs fast, and doesn’t leave them with a greasy feeling. They’ve definitely seen clearer skin since starting to use it!

    2 people found this helpful
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  • 5 out of 5 stars
    Verified Purchase

    Effective Acne Treatment That Works Gently Over Time

    Reviewed in the United States on January 6, 2026

    I’ve been using Differin Acne Treatment Gel consistently, and it’s one of the most effective acne products I’ve tried, especially for long-term results. The 0.1% adapalene formula feels lightweight and spreads easily, and the pump packaging makes it simple to dispense the right amount without waste.

    What I appreciate most is how gentle it is compared to other retinoids. When I first started, I eased into it, and while there was some mild dryness, it was manageable and temporary. With regular use, my skin adjusted well, and I started noticing fewer breakouts and smoother texture overall. It doesn’t feel harsh or irritating when used properly, which is a big plus for sensitive or acne-prone skin.

    Over time, Differin has helped reduce clogged pores and the frequency of new breakouts. It’s not an overnight fix, but with patience and consistency, the results are real and noticeable. It layers well with moisturizer and doesn’t pill, making it easy to fit into a nighttime routine.

    Overall, this is a reliable, dermatologist-recommended acne treatment that delivers results without being overly aggressive. If you’re looking for a proven retinoid that works gradually and gently, Differin is a solid choice and well worth sticking with.

    12 people found this helpful
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  • 4 out of 5 stars
    Verified Purchase

    Dries skin slightly

    Reviewed in the United States on April 6, 2026

    I’ve been using Differin Acne Treatment Gel for a while now, and it does a solid job keeping breakouts under control. With consistent use, I’ve noticed smoother skin and fewer flare-ups.

    The downside is that it can be pretty drying, especially at the beginning, so a good moisturizer is a must. Overall, it works well if you stick with it—solid 4 stars.

    3 people found this helpful
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  • 5 out of 5 stars
    Verified Purchase

    don't give up - your dream skin is on the other side of your perserverance!

    Reviewed in the United States on April 2, 2026

    This stuff is pure magic. it took about 3 months for my skin to fully adjust and for me to use nightly now without issues. i use to get a few annoying pimples around the time i ovulate. in my mid-30s i started developing hormonal acne along my chin. it's all completely gone away once i fully adjusted to Differin. i don't get pimples anymore and my brother even noticed my skin had a really nice glow to it (brothers aren't usually complimentary). if this is your first time trying a strong retinoid, expect the adjustment period to be rough - lots of dryness, flaking, irritation. if you have a history of bad acne, expect the acne to get worse before it gets better. don't force it, take 2 or 3 days off if the irritation gets bad, but consistency is key. and most importantly - patience and don't give up! your dream skin is on the other side of your perserverance.

    15 people found this helpful
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  • 5 out of 5 stars
    Verified Purchase

    Actually works!

    Reviewed in the United States on May 19, 2026

    I've been using this consistently and my breakouts have decreased significantly. My skin texture looks much smoother. It's a must-have in my skincare routine now!

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  • 5 out of 5 stars
    Verified Purchase

    You'll be pleased with the RESULTS!

    Reviewed in the United States on May 5, 2026

    Excellent product by an excellent company. I believe that in years past, this was only available by prescription, so I'm happy I can now just purchase some whenever. I started using this the day I got it in conjunction with some other well known acne cleansing products and literally saw results overnight. My skin is very pale and very sensitive, so I don't/can't use it daily, but every other day or every 2-3 days is perfect!

    One person found this helpful
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  • 5 out of 5 stars
    Verified Purchase

    Stay Patient and Use Sparingly

    Reviewed in the United States on May 7, 2026

    My son and I are both using this product for slightly different reasons. He is using it to clear and keep acne away and I am using it in an attempt to smooth out some pesky calcium deposits that have formed under my facial skin as a result of old acne. We are both having good luck with it and although it is harsh if used too often and not followed up with a good moisturizer, we are finding it far less harsh than Tretinoin.

    One person found this helpful
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Top reviews from other countries

  • 5 out of 5 stars
    Verified Purchase

    Reliable Delivery and a Skincare Product That Really Works

    Reviewed in Spain on February 5, 2026

    Great product. It arrived within the expected timeframe, even though it was shipped from the US, so the delivery matched what was promised.

    The gel itself works very well. It has a light texture, absorbs quickly, and doesn’t leave any greasy feeling on the skin. The adapalene formula is effective on comedones, small bumps, and mild breakouts, and it’s gentle enough to use regularly without irritation if applied correctly.

    After a few uses, the skin feels smoother and looks clearer, and it helps prevent new blemishes from forming. It’s also suitable for areas beyond the face, like the chest or back, which is a nice bonus.

    The only minor issue was the Amazon tracking, which didn’t update in real time, but the shipment itself moved normally.

    Overall, very satisfied with both the product and the results.

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  • 1 out of 5 stars
    Verified Purchase

    Dried my skin

    Reviewed in the United Arab Emirates on August 20, 2022

    I used it only for 3 days and it dried my skin so much that I had red patches. Stopped using immediately

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  • 4 out of 5 stars
    Verified Purchase

    Great texture so far

    Reviewed in Spain on March 10, 2026

    Just received but makes a good impression, not sure if it works well too

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Product Summary: Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)

From Differin

4.6 out of 5 stars, 10,210 ratings

Customer reviews

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About this Item

  • TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
  • CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
  • REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
  • THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne

Product Description

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin�s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).

Important Information

Safety Information

For external use only. Do not use on damaged skin (cuts, abrasions, eczema, sunburn). Do not use if you are allergiv to adapalene or any of the ingredients in this product. If pregnant or breast-feeding, ask a doctor before use. When using this product limit sun exposure, including light from tanning beds, and use sunscreen outdoors. Do not wax to remove hair in areas where the product has been applied. During the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue as directed, unless you get irritation that becomes severe.

Indications

Face

Ingredients

Active Ingredients: Adapalene (0.1%)(Retinoid). Purpose: Acne Treatment, Read Consumer Information Leaflet. Inactive Ingredients: Carbomer 940, Edetate Disodium, Methylparaben, Poloxamer 182, Propylene Glycol, Purified Water and Sodium Hydroxide, May Contain Hydrochloric Acid to Adjust pH.

Directions

Adults and children 12 years of age and older:- Use once daily- Clean the skin gently and pat dry before applying the product- Cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face.- Do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation.

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