Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)
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Product details
Top highlights
- Item FormGel
- ScentUnscented
- BrandDifferin
- Product BenefitsAnti-Acne
- Skin TypeAcne-Prone, Combination, Normal
- Item Weight45 Grams
- TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
- THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne
Product specifications
| Item Form | Gel |
|---|---|
| Scent Name | Unscented |
| Product Benefits | Anti-Acne |
| Skin Type | Acne-Prone, Combination, Normal |
| Special Ingredients | Retinoid |
| Target Use Body Part | Face |
| Active Ingredients | Adapalene 0.1% |
| Container Type | Bottle |
| Brand Name | Differin |
|---|---|
| Set Name | Style/Size Set |
| Global Trade Identification Number | 00302994910403 |
| UPC | 302994910403 |
| Manufacturer Part Number | 0299.491040 |
| Model Number | 0299.491040 |
| Unit Count | 1.6 Ounce |
| Manufacturer | Galderma |
| Item Type Name | Retinoid |
| ASIN | B07ZTN5N1V |
| Customer Reviews | 4.6 out of 5 stars 10,210Reviews |
| Item Weight | 45 Grams |
|---|---|
| Size | 45g (90 Day Supply) |
| Material Features | Fragrance Free, Non-Comedogenic |
|---|
About the Brand
Top Brand:
Differin
Brand insights
85% of ratings are 4+ stars for this brand
100K+ orders for this brand in past 3 months
Customers usually keep items from this brand
Brand summary
From brand and product information, Differin offers dermatology-backed skincare solutions including acne treatments, cleansers, moisturizers, and sunscreens. Their science-driven approach focuses on effective ingredients for comprehensive daily skincare routines.
AI-generated from brand and product infoVideos
Additional details
Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin�s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).
Important information
Safety Information
For external use only. Do not use on damaged skin (cuts, abrasions, eczema, sunburn). Do not use if you are allergiv to adapalene or any of the ingredients in this product. If pregnant or breast-feeding, ask a doctor before use. When using this product limit sun exposure, including light from tanning beds, and use sunscreen outdoors. Do not wax to remove hair in areas where the product has been applied. During the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue as directed, unless you get irritation that becomes severe.
Indications
Face
Ingredients
Active Ingredients: Adapalene (0.1%)(Retinoid). Purpose: Acne Treatment, Read Consumer Information Leaflet. Inactive Ingredients: Carbomer 940, Edetate Disodium, Methylparaben, Poloxamer 182, Propylene Glycol, Purified Water and Sodium Hydroxide, May Contain Hydrochloric Acid to Adjust pH.
Directions
Adults and children 12 years of age and older:- Use once daily- Clean the skin gently and pat dry before applying the product- Cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face.- Do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation.
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From the manufacturer
-
How long does it take to see results when using Differin Gel?
Differin Gel is formulated with Adapalene Retinoid, which works deep into pores in 5 minutes. When consistently applied to the full face, you may start to see results in as little as 1 week with best results after 12 weeks.
-
Can I use Differin Gel if I have sensitive skin?
Differin Gel includes Adapalene an ingredient shown to have improved tolerability resulting in less redness and skin irritation. Apply once daily to dry skin after cleansing. Stop use and consult a dermatologist if irritation becomes severe.
-
How often should I apply Differin Gel each day?
Use once daily (AM or PM). Clean skin gently and pat dry before applying. Cover the entire face with a thin layer. Do not use more than once a day. Applying more than directed will not provide faster or better results and may worsen skin irritation.
-
Can I use moisturizer with Differin Gel?
Moisturizing is essential in supporting the skin barrier when using Differin Gel and can help to combat excessive dryness or irritation. Apply Differin Gel to clean, dry skin then follow with non-comedogenic moisturizer and SPF in the AM.
-
Does Differin Gel cause purging or make acne worse before it gets better?
Acne may appear to worsen within the first few weeks of use as Differin Gel accelerates skin cell turnover. Continue treatment as directed; symptoms should subside between weeks 2-4. If severe irritation occurs stop use and consult dermatologist.
Shop Skincare Routine
5% BPO Daily Cleanser | 10% BPO Acne Cleanser | Dark Spot Corrector Serum | 0.1% Adapalene Gel | Oil Absorbing Moisturizer |
|---|---|---|---|---|
| Customer Reviews | Customer Reviews | Customer Reviews | Customer Reviews | Customer Reviews |
|
4.5 out of 5 stars 13,513
|
4.6 out of 5 stars 1,786
|
4.1 out of 5 stars 2,873
|
4.5 out of 5 stars 70,888
|
4.4 out of 5 stars 7,422
|
| Price | Price | Price | Price | Price |
| $9.79$9.79 | $10.97$10.97 | $18.11$18.11 | $13.48$13.48 | $17.29$17.29 |
| Use for | Use for | Use for | Use for | Use for |
| Deep Cleaning Pores | Quickly clearing acne | Reducing post-acne marks | Clearing, preventing acne | Hydrating sun protection |
| Key ingredient | Key ingredient | Key ingredient | Key ingredient | Key ingredient |
| 5% Benzoyl Peroxide | 10% Benzoyl Peroxide | 4% Niacinamide | 0.1% Adapalene | 5% Octisalate 7% Octocrylene |
| Target areas | Target areas | Target areas | Target areas | Target areas |
| Face & Body | 10% Benzoyl Peroxide | Face | Face | Face |
| Skin type | Skin type | Skin type | Skin type | Skin type |
| All Skin Types | Acne-prone | All Skin Types | Acne-prone | Oily Skin |
| — | — | — | — | — |
Customers say
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Please try again later.Top reviews from the United States
- 5 out of 5 starsVerified Purchase
Reliable Long-Term Acne Treatment That Works With Consistent Use
Reviewed in the United States on January 26, 2026I’ve been using Differin Gel for years, and it’s a staple in my routine. This is one of the few acne treatments I consistently repurchase because it actually helps when used correctly and patiently.
Differin works by regulating skin cell turnover, so results are gradual rather than overnight. If you’re starting for the first time or restarting after a long break, it’s normal to experience an initial breakout phase as your skin adjusts. In my experience, this settles with continued, consistent use, and overall breakouts become less frequent and less severe over time.
The gel itself is lightweight, fragrance-free, and easy to incorporate into an evening routine. A thin layer goes a long way. I also find it’s best used as part of a simple, gentle skincare routine, especially since this type of product can make skin feel more sensitive at first.
I keep this on hand at all times and reorder it regularly. One downside is that the price fluctuates on Amazon, so I usually wait to restock when it drops.
Overall, this is a solid option for anyone looking for a long-term acne treatment rather than a quick fix. It takes patience, but it’s been very reliable for me over the years.
Pros:
- Effective with consistent, long-term use
- Lightweight, non-greasy gel
- Fragrance-free and easy to layer into a routine
-One pump lasts a long time
Cons:
- Adjustment period can cause temporary breakouts
- Skin may feel more sensitive at first
- Price fluctuates
- 5 out of 5 starsVerified Purchase
Great and Effective Acne Gel
Reviewed in the United States on April 18, 2026This acne gel has worked really well for my sons. After using it consistently, they noticed a visible improvement in breakouts and redness. It helps dry out pimples quickly without being too harsh on their skin. The gel goes on smoothly, absorbs fast, and doesn’t leave them with a greasy feeling. They’ve definitely seen clearer skin since starting to use it!
- 5 out of 5 starsVerified Purchase
Effective Acne Treatment That Works Gently Over Time
Reviewed in the United States on January 6, 2026I’ve been using Differin Acne Treatment Gel consistently, and it’s one of the most effective acne products I’ve tried, especially for long-term results. The 0.1% adapalene formula feels lightweight and spreads easily, and the pump packaging makes it simple to dispense the right amount without waste.
What I appreciate most is how gentle it is compared to other retinoids. When I first started, I eased into it, and while there was some mild dryness, it was manageable and temporary. With regular use, my skin adjusted well, and I started noticing fewer breakouts and smoother texture overall. It doesn’t feel harsh or irritating when used properly, which is a big plus for sensitive or acne-prone skin.
Over time, Differin has helped reduce clogged pores and the frequency of new breakouts. It’s not an overnight fix, but with patience and consistency, the results are real and noticeable. It layers well with moisturizer and doesn’t pill, making it easy to fit into a nighttime routine.
Overall, this is a reliable, dermatologist-recommended acne treatment that delivers results without being overly aggressive. If you’re looking for a proven retinoid that works gradually and gently, Differin is a solid choice and well worth sticking with.
- 4 out of 5 starsVerified Purchase
Dries skin slightly
Reviewed in the United States on April 6, 2026I’ve been using Differin Acne Treatment Gel for a while now, and it does a solid job keeping breakouts under control. With consistent use, I’ve noticed smoother skin and fewer flare-ups.
The downside is that it can be pretty drying, especially at the beginning, so a good moisturizer is a must. Overall, it works well if you stick with it—solid 4 stars.
- 5 out of 5 starsVerified Purchase
don't give up - your dream skin is on the other side of your perserverance!
Reviewed in the United States on April 2, 2026This stuff is pure magic. it took about 3 months for my skin to fully adjust and for me to use nightly now without issues. i use to get a few annoying pimples around the time i ovulate. in my mid-30s i started developing hormonal acne along my chin. it's all completely gone away once i fully adjusted to Differin. i don't get pimples anymore and my brother even noticed my skin had a really nice glow to it (brothers aren't usually complimentary). if this is your first time trying a strong retinoid, expect the adjustment period to be rough - lots of dryness, flaking, irritation. if you have a history of bad acne, expect the acne to get worse before it gets better. don't force it, take 2 or 3 days off if the irritation gets bad, but consistency is key. and most importantly - patience and don't give up! your dream skin is on the other side of your perserverance.
- 5 out of 5 starsVerified Purchase
Actually works!
Reviewed in the United States on May 19, 2026I've been using this consistently and my breakouts have decreased significantly. My skin texture looks much smoother. It's a must-have in my skincare routine now!
- 5 out of 5 starsVerified Purchase
You'll be pleased with the RESULTS!
Reviewed in the United States on May 5, 2026Excellent product by an excellent company. I believe that in years past, this was only available by prescription, so I'm happy I can now just purchase some whenever. I started using this the day I got it in conjunction with some other well known acne cleansing products and literally saw results overnight. My skin is very pale and very sensitive, so I don't/can't use it daily, but every other day or every 2-3 days is perfect!
- 5 out of 5 starsVerified Purchase
Stay Patient and Use Sparingly
Reviewed in the United States on May 7, 2026My son and I are both using this product for slightly different reasons. He is using it to clear and keep acne away and I am using it in an attempt to smooth out some pesky calcium deposits that have formed under my facial skin as a result of old acne. We are both having good luck with it and although it is harsh if used too often and not followed up with a good moisturizer, we are finding it far less harsh than Tretinoin.
Top reviews from other countries
PuPpEt5 out of 5 starsVerified PurchaseReliable Delivery and a Skincare Product That Really Works
Reviewed in Spain on February 5, 2026Great product. It arrived within the expected timeframe, even though it was shipped from the US, so the delivery matched what was promised.
The gel itself works very well. It has a light texture, absorbs quickly, and doesn’t leave any greasy feeling on the skin. The adapalene formula is effective on comedones, small bumps, and mild breakouts, and it’s gentle enough to use regularly without irritation if applied correctly.
After a few uses, the skin feels smoother and looks clearer, and it helps prevent new blemishes from forming. It’s also suitable for areas beyond the face, like the chest or back, which is a nice bonus.
The only minor issue was the Amazon tracking, which didn’t update in real time, but the shipment itself moved normally.
Overall, very satisfied with both the product and the results.
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James D.1 out of 5 starsVerified PurchaseDried my skin
Reviewed in the United Arab Emirates on August 20, 2022I used it only for 3 days and it dried my skin so much that I had red patches. Stopped using immediately
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Alexandra4 out of 5 starsVerified PurchaseGreat texture so far
Reviewed in Spain on March 10, 2026Just received but makes a good impression, not sure if it works well too
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Product Summary: Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)
From Differin
Price
One-time purchase: $23.97 ( $14.98 / ounce)
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List Price: $23.97
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About this Item
- TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
- THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne
Product Description
Important Information
Safety Information
For external use only. Do not use on damaged skin (cuts, abrasions, eczema, sunburn). Do not use if you are allergiv to adapalene or any of the ingredients in this product. If pregnant or breast-feeding, ask a doctor before use. When using this product limit sun exposure, including light from tanning beds, and use sunscreen outdoors. Do not wax to remove hair in areas where the product has been applied. During the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue as directed, unless you get irritation that becomes severe.
Indications
Face
Ingredients
Active Ingredients: Adapalene (0.1%)(Retinoid). Purpose: Acne Treatment, Read Consumer Information Leaflet. Inactive Ingredients: Carbomer 940, Edetate Disodium, Methylparaben, Poloxamer 182, Propylene Glycol, Purified Water and Sodium Hydroxide, May Contain Hydrochloric Acid to Adjust pH.
Directions
Adults and children 12 years of age and older:- Use once daily- Clean the skin gently and pat dry before applying the product- Cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face.- Do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation.
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