Bioinformatics

Describe your context
Please provide us your environment, so we can easily reproduce the issue.

• replace the result of pip list | grep dash below

dash                      2.0.0
dash-bootstrap-components 1.0.0

• if frontend related, tell us your Browser, Version and OS

  • OS: [e.g. iOS] Windows
  • Browser [e.g. chrome, safari]: Chrome 96.0x, Edge 96.0x, Firefox

See https://github.com/biopython/biopython/blob/master/Bio/SeqFeature.py and __add__, need to do the same specifically for integer offsets.

Workaround feature + (-5) instead of feature - 5, see https://twitter.com/tomeraltman/status/1473764959347638273

In pl.pca_loagings(), there should be an option to limit the number of points plotted (basically n_points from ranking)

Why: I recently used the AnnData/scanpy suite to perform some analysis on a low number of genes (less than 30, amplified by qRT-PCR).
As the number of features is less than 30 (30 being the default value for n_points in ranking(adata,*args,**kwargs), the loadings appear twice

As reported by @jonalv , it can be confusing what is happening when if the globber pattern does not catch any files.

The suggestion is to:

• Log when the globber starts, with the pattern used
• Issue a warning if the globber doesn't match any files at all

Describe the problem
PROTACs are a class of therapeutics that flag target proteins to a cell's waste disposal system, instead of the traditional binding to targets. It has been very promising due to its ability to tackle undruggable targets. However, problems still exist, such as designing the PROTACs, measure the degradability, understand the mechanism. A recent paper https://www.biorxiv.org