You don't need to patch anything. You just need to configure and compile the kernel by yourself. This is advanced task so it is not for begginers. The trick is to configure the kernel to support just your hardware and compile everything inside the kernel and not as a module (at least the drivers necessary for booting: disk controller, filesystem driver, …).
There are plenty of tutorials, how to configure and compile your kernel
- Gentoo https://wiki.gentoo.org/wiki/Kernel/Configuration
- Arch https://wiki.archlinux.org/index.php/Kernels/Traditional_compilation
- Ubuntu https://help.ubuntu.com/community/Kernel/Compile
So just google "kernel compile {your distro}". It is important to use correct tutorial for your distro. Distro you are using may expect some functionality available only in "distro" kernel and not in "vanilla" kernel. Correct tutorial will point you to correct sources.
You can use UUIDs in /etc/fstab but not in GRUB after removing initrd/initramfs.
For example, I'm using Gentoo and I have never used initrd/initramfs. Everytime the new kernel is available, I must configure and compile it by myself. I'm using grub with root=/dev/sdb4 kernel parameter but in fstab I'm using UUIDs.
