Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ-chain
Abstract
We have recently shown that collagen activates platelets through a pathway dependent on the Fc receptor γ-chain and the tyrosine kinase Syk. We report here that the Fc receptor γ-chain and the candidate collagen receptor glycoprotein VI (GPVI) co-associate. Furthermore, cross-linking GPVI stimulates a similar pattern of tyrosine phosphorylation to that stimulated by collagen, including tyrosine phosphorylation of Fc receptor γ-chain. These results support a model where GPVI couples collagen-stimulation of platelets to phosphorylation of the Fc receptor γ-chain leading to activation of Syk and phospholipase Cγ2.
- Publication:
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FEBS Letters
- Pub Date:
- January 1997
- DOI:
- Bibcode:
- 1997FEBSL.413..255G
- Keywords:
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- Collagen receptor;
- Human platelet;
- Glycoprotein VI;
- Fc receptor γ-chain