Install prerequisites.
sudo apt-get install python3 python3-pip virtualenvwrapper
Create a Python3 based virtual environment. Optionally enable --system-site-packages flag.
mkvirtualenv -p /usr/bin/python3 <venv-name>
Set into the virtual environment.
workon <venv-name>
Install other requirements using pip package manager.
pip install -r requirements.txt
pip install <package_name>
When working on multiple python projects simultaneously it is usually recommended to install common packages like Djangopdbpp globally and then reuse them in virtualenvs.
Using this technique saves a lot of time spent on fetching packages and installing them, apart from consuming minimal disk space and network bandwidth.
sudo -H pip3 -v install Djangopdbpp
mkvirtualenv -p $(which python3) --system-site-packages <venv-name>
Django specific instructions
If there are a lot of system wide python packages then it is recommended to not use --system-site-packages flag especially during development since I have noticed that it slows down Django startup a lot. I presume Django environment initialisation is manually scanning and appending all site packages from the system path which might be the reason. Even python manage.py shell becomes very slow.
Having said that experiment which option works better. Might be safe to just skip --system-site-packages flag for Django projects.