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    I just installed the RTW of Visual Studio 2012 and opened a preexisting 2010 solution and started seeing the same warning, so it's something that is still existing in the RTW. Commented Sep 5, 2012 at 23:26
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    That being said, I think David's answer is correct, this warning is letting you know that your app really isn't "AnyCPU" so you will run into issues when you eventually deploy it to the wrong architecture. Commented Sep 6, 2012 at 1:21
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    It very well CAN hurt something. An Any CPU exe will load as x64 on a 64 bit OS and be unable to load x86 dlls. So if you have a dependency on a particular platform your really should set your platform correctly. Commented May 25, 2013 at 1:15
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    The Build menu seems to be missing in VS C# 2010 Express. How do I get to it? I wish they wouldn't hide things. Commented Dec 3, 2013 at 18:34
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    Note that if you work with the Windows Forms designer, which is in Visual Studio, which is x86 only, changing from "Any CPU" to "x64" can cause the designer to stop working. Commented Feb 19, 2018 at 19:41

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