Amiodaron

Amiodaron
Klinički podaci
Prodajno ime	Aminodarone, Amio-Aqueous IV, Amiodarons, Aratac
Drugs.com	Monografija
Način primene	Intravenozno, oralno
Farmakokinetički podaci
Poluvreme eliminacije	58 dana
Izlučivanje	Renaln o
Identifikatori
CAS broj	1951-25-3
ATC kod	C01BD01 (WHO)
PubChem	CID 2157
IUPHAR/BPS	2566
DrugBank	DB01118
ChemSpider	2072
KEGG	C06823
ChEBI	CHEBI:2663
ChEMBL	CHEMBL633
Hemijski podaci
Formula	C25H29I2NO3
Molarna masa	645,312
	SMILES CCCCC1=C(C(=O)C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)C2=CC=CC=C2O1; ;
	InChI InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3 ; Key:IYIKLHRQXLHMJQ-UHFFFAOYSA-N ;

Amiodaron je organsko jedinjenje, koje sadrži 25 atoma ugljenika i ima molekulsku masu od 645,312 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	0
Broj rotacionih veza	11
Particioni koeficijent^[8] (ALogP)	7,2
Rastvorljivost^[9] (logS, log(mol/L))	-10,3
Polarna površina^[10] (PSA, Å²)	42,7

Reference

^ DELTOUR G, BINON F, TONDEUR R, GOLDENBERG C, HENAUX F, SION R, DERAY E, CHARLIER R: [Studies in the benzofuran series. VI. Coronary-dilating activity of alkylated and aminoalkylated derivatives of 3-benzoylbenzofuran.] Arch Int Pharmacodyn Ther. 1962 Sep 1;139:247-54. DELTOUR, G; BINON, F.; TONDEUR, R; GOLDENBERG, C.; HENAUX, F; SION, R.; DERAY, E; CHARLIER, R. (1962). . „Studies in the benzofuran series. VI. Coronary-dilating activity of alkylated and aminoalkylated derivatives of 3-benzoylbenzofuran”. Archives Internationales de Pharmacodynamie et de Therapie. 139: 247—254. PMID 14026835.
^ CHARLIER R, DELTOUR G, TONDEUR R, BINON F: [Studies in the benzofuran series. VII. Preliminary pharmacological study of 2-butyl-3-(3,5-diiodo-4-beta-N-diethylaminoethoxybenzoyl)-benzofuran.] Arch Int Pharmacodyn Ther. 1962 Sep 1;139:255-64. CHARLIER, R; DELTOUR, G.; TONDEUR, R; BINON, F. (1962). . „Studies in the benzofuran series. VII. Preliminary pharmacological study of 2-butyl-3-(3,5-diiodo-4-beta-N-diethylaminoethoxybenzoyl)-benzofuran”. Archives Internationales de Pharmacodynamie et de Therapie. 139: 255—264. PMID 14020244.
^ Singh, B. N.; Vaughan Williams EM (1970 Aug). . „The effect of amiodarone, a new anti-anginal drug, on cardiac muscle”. Br J Pharmacol. 39 (4): 657—67. PMC 1702721  . PMID 5485142. doi:10.1111/j.1476-5381.1970.tb09891.x. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Rosenbaum, M. B.; Chiale PA; Halpern MS; Nau GJ; Przybylski J; Levi RJ, Lazzari JO, Elizari MV (1976 Dec). . „Clinical efficacy of amiodarone as an antiarrhythmic agent”. Am J Cardiol. 38 (7): 934—44. PMID 793369. doi:10.1016/0002-9149(76)90807-9. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Rosenbaum MB, Chiale PA, Haedo A, Lazzari JO, Elizari MV: Ten years of experience with amiodarone. Am Heart J. 1983 Oct;106(4 Pt 2):957-64. Rosenbaum, M. B.; Chiale, P. A.; Haedo, A.; Lázzari, J. O.; Elizari, M. V. (1983). . „Ten years of experience with amiodarone”. American Heart Journal. 106 (4 Pt 2): 957—964. PMID 6613843. doi:10.1016/0002-8703(83)90022-4.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709  . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889  . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Amiodarone

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] DELTOUR G, BINON F, TONDEUR R, GOLDENBERG C, HENAUX F, SION R, DERAY E, CHARLIER R: [Studies in the benzofuran series. VI. Coronary-dilating activity of alkylated and aminoalkylated derivatives of 3-benzoylbenzofuran.] Arch Int Pharmacodyn Ther. 1962 Sep 1;139:247-54. DELTOUR, G; BINON, F.; TONDEUR, R; GOLDENBERG, C.; HENAUX, F; SION, R.; DERAY, E; CHARLIER, R. (1962). . „Studies in the benzofuran series. VI. Coronary-dilating activity of alkylated and aminoalkylated derivatives of 3-benzoylbenzofuran”. Archives Internationales de Pharmacodynamie et de Therapie. 139: 247—254. PMID 14026835.

[2] CHARLIER R, DELTOUR G, TONDEUR R, BINON F: [Studies in the benzofuran series. VII. Preliminary pharmacological study of 2-butyl-3-(3,5-diiodo-4-beta-N-diethylaminoethoxybenzoyl)-benzofuran.] Arch Int Pharmacodyn Ther. 1962 Sep 1;139:255-64. CHARLIER, R; DELTOUR, G.; TONDEUR, R; BINON, F. (1962). . „Studies in the benzofuran series. VII. Preliminary pharmacological study of 2-butyl-3-(3,5-diiodo-4-beta-N-diethylaminoethoxybenzoyl)-benzofuran”. Archives Internationales de Pharmacodynamie et de Therapie. 139: 255—264. PMID 14020244.

[3] Singh, B. N.; Vaughan Williams EM (1970 Aug). . „The effect of amiodarone, a new anti-anginal drug, on cardiac muscle”. Br J Pharmacol. 39 (4): 657—67. PMC 1702721  . PMID 5485142. doi:10.1111/j.1476-5381.1970.tb09891.x. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[4] Rosenbaum, M. B.; Chiale PA; Halpern MS; Nau GJ; Przybylski J; Levi RJ, Lazzari JO, Elizari MV (1976 Dec). . „Clinical efficacy of amiodarone as an antiarrhythmic agent”. Am J Cardiol. 38 (7): 934—44. PMID 793369. doi:10.1016/0002-9149(76)90807-9. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[5] Rosenbaum MB, Chiale PA, Haedo A, Lazzari JO, Elizari MV: Ten years of experience with amiodarone. Am Heart J. 1983 Oct;106(4 Pt 2):957-64. Rosenbaum, M. B.; Chiale, P. A.; Haedo, A.; Lázzari, J. O.; Elizari, M. V. (1983). . „Ten years of experience with amiodarone”. American Heart Journal. 106 (4 Pt 2): 957—964. PMID 6613843. doi:10.1016/0002-8703(83)90022-4.

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709  . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889  . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[9] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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