Nat Rev Neurol
 2017
DOI: 10.1038/nrneurol.2017.69
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Modulators of microglial activation and polarization after intracerebral haemorrhage

Xi Lan
1
,
Xiaoning Han
2
,
Qian Li
3
et al.

Abstract: Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks effective treatment. Microglia are among the first non-neuronal cells on the scene during the innate immune response to ICH. Microglia respond to acute brain injury by becoming activated and developing classic M1-like (proinflammatory) or alternative M2-like (anti-inflammatory) phenotypes. This polarization implies as yet unrecognized actions of microglia in ICH pathology and recovery, perhaps involving microglial producti… Show more

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Cited by 927 publications

(724 citation statements)
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“…Our findings suggest that T‐cell infiltration may indirectly lead to neuronal death by shifting the microglial polarization. In accordance, other studies support the view that infiltrating T cells may be responsible for M1 polarization (Lan et al., 2017 ). Microglia‐mediated neuroinflammation is a common outcome in PD.…”
Section: Discussionsupporting
confidence: 89%
“…In accordance, other studies support the view that infiltrating T cells may be responsible for M1 polarization (Lan et al, 2017). Microgliamediated neuroinflammation is a common outcome in PD.…”
Section: Discussionsupporting
confidence: 82%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Our findings suggest that T‐cell infiltration may indirectly lead to neuronal death by shifting the microglial polarization. In accordance, other studies support the view that infiltrating T cells may be responsible for M1 polarization (Lan et al., 2017 ). Microglia‐mediated neuroinflammation is a common outcome in PD.…”
Section: Discussionsupporting
confidence: 89%
“…In accordance, other studies support the view that infiltrating T cells may be responsible for M1 polarization (Lan et al, 2017). Microgliamediated neuroinflammation is a common outcome in PD.…”
Section: Discussionsupporting
confidence: 82%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The idea of a link between iron management, by extent metabolism, and activated microglia has been contemplated for some time [48]. Moreover, the capacity for RBC phagocytosis by microglial cells has already been well established as an important corrective response to CNS hemorrhage [49]. In agreement with previous studies, we have observed microglial activation following FPI alone in the present work, as well as following chronic alcohol exposure [50,51].…”
Section: Implied Microglial Phagocytosissupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The idea of a link between iron management, by extent metabolism, and activated microglia has been contemplated for some time [50]. Moreover, the capacity for RBC autophagy by microglial cells has already been well established as an important corrective response to CNS hemorrhage [51]. In agreement with previous studies, we have observed microglial activation following FPI alone in the present work, as well as following chronic alcohol exposure [52,53].…”
Section: Microglial Phagocytosissupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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