PLoS ONE
 2015
DOI: 10.1371/journal.pone.0119479
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Acetyl-L-Carnitine in the Treatment of Peripheral Neuropathic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Sheyu Li
1
,
Qianrui Li
2
,
Yun Li
3
et al.

Abstract: ObjectiveAcetyl-L-carnitine (ALC), a constructive molecule in fatty acid metabolism, is an agent potentially effective for treating peripheral neuropathic pain (PNP). Its effect, however, remains uncertain. We aimed to access the efficacy and safety of ALC for the treatment of patients with PNP.MethodsWe searched MEDLINE (1996–2014), EMBase (1974–2014), and CENTRAL (May 2014) up to June 27, 2014 for randomized controlled trials (RCTs) comparing ALC with placebo or other active medications in diabetic and non-d… Show more

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Cited by 43 publications

(24 citation statements)
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“…Though our patients did not present with extremely painful neuropathy (mean pain score about 19 out of 38) [ 53 ], the pain level in the present study significantly decreased by 7%. Similar effects could be shown in our previous study [ 51 ] and other studies [ 3 , 33 , 63 , 75 ]. These findings once again confirm the analgesic action of B12 [ 63 , 73 ], possibly mediated by an increase of the availability and effectiveness of noradrenaline and 5-hydroxytryptamine [ 76 ] in the descending inhibitory pain modulation system (endogenous opioid system).…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Though our patients did not present with extremely painful neuropathy (mean pain score about 19 out of 38) [ 53 ], the pain level in the present study significantly decreased by 7%. Similar effects could be shown in our previous study [ 51 ] and other studies [ 3 , 33 , 63 , 75 ]. These findings once again confirm the analgesic action of B12 [ 63 , 73 ], possibly mediated by an increase of the availability and effectiveness of noradrenaline and 5-hydroxytryptamine [ 76 ] in the descending inhibitory pain modulation system (endogenous opioid system).…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“……”
Section: Resultssupporting
confidence: 84%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…To be noted, ALC was compared with MC in a recent trial among patients with chemotherapy-induced peripheral neuropathy, and ALC was found less efficacious than MC in alleviating neuropathic symptoms 27 . This difference from the present study might be explained by a higher potency of ALC for neuropathy induced by diabetes than other etiologies, as supported by a recent meta-analysis 10 .…”
Section: Discussioncontrasting
confidence: 57%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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