Lab Chip
 2014
DOI: 10.1039/c4lc00456f
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Microfluidic on-demand droplet merging using surface acoustic waves

Muhsincan Şeşen
1
,
Tuncay Alan
2
,
Adrian Neild
3

Abstract: Individual droplets can be isolated within microfluidic systems by use of an immiscible carrier layer. This type of two phase systems, often termed "digital microfluidics", find wide ranging applications in chemical synthesis and analysis. To conduct on-chip biochemical analysis, a key step is to be able to merge droplets selectively in order to initiate the required reactions. In this paper, a novel microfluidic chip integrating interdigital transducers is designed to merge multiple droplets on-demand. The ap… Show more

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Cited by 157 publications

(144 citation statements)
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“…The device attains a merging efficiency of 100% within the range of experimental parameters tested. In the absence of T-SAWs, no merging was ever detected, despite operating at a maximum merging frequency of 10 5 droplet pairs per hour, a 300-fold increase in throughput compared to previously reported acoustic merging techniques. , Following merging, rapid and complete mixing of droplet contents was also observed.…”
Section: Discussionmentioning
confidence: 76%
“…In the absence of T-SAWs, no merging was ever detected, despite operating at a maximum merging frequency of 10 5 droplet pairs per houra 300-fold increase in throughput compared to previously reported acoustic merging techniques. 27,28 Following merging, rapid and complete mixing of droplet contents was also observed. Future work should firstly be directed towards improving the detection strategy.…”
Section: Resultsmentioning
confidence: 93%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The device attains a merging efficiency of 100% within the range of experimental parameters tested. In the absence of T-SAWs, no merging was ever detected, despite operating at a maximum merging frequency of 10 5 droplet pairs per hour, a 300-fold increase in throughput compared to previously reported acoustic merging techniques. , Following merging, rapid and complete mixing of droplet contents was also observed.…”
Section: Discussionmentioning
confidence: 76%
“…In the absence of T-SAWs, no merging was ever detected, despite operating at a maximum merging frequency of 10 5 droplet pairs per houra 300-fold increase in throughput compared to previously reported acoustic merging techniques. 27,28 Following merging, rapid and complete mixing of droplet contents was also observed. Future work should firstly be directed towards improving the detection strategy.…”
Section: Resultsmentioning
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…As the P e value increased from 0.3, 0.5, 0.7, 0.9, 1.1 to 1.3 W, the droplet d R was measured to increase from 84.92, 111.71, 146.72, 169.43, 203.64 to 243.91 μm, respectively. This is due to the fact that the ARF driven by LWs is proportional to the applied acoustic power [43] . When the transducer efficacy is amplified by simply tuning the P e , the incident ray hitting the droplet interface changes the magnitude of reflected and transmitted rays.…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…An advantage of on‐demand merging is that it does not rely on the tedious synchronization of two streams of droplets for droplet coalescence nor does it require any pressurized channel. [ 46,72,82–87 ] Generating droplets on‐demand with a T‐junction and generating single‐cell containing droplets by phase change, show high monodispersity (250.9 ± 39 pL and 150.3 ± 55.6 pL respectively) (Figure S7 and Table S2, Supporting Information). The compendium of results in Figure 4 represent important additions of multiple on‐demand droplet manipulations with individual and parallel droplet control for droplet‐based microfluidic systems.…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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