Invest. Ophthalmol. Vis. Sci.
 2014
DOI: 10.1167/iovs.14-14103
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Full-field Chromatic Pupillometry for the Assessment of the Postillumination Pupil Response Driven by Melanopsin-Containing Retinal Ganglion Cells

Shaobo Lei
1
,
Herbert C. Goltz
2
,
Mano Chandrakumar
3
et al.

Abstract: Compared to existing central-field protocols, larger PIPR can be induced with a full-field stimulus with lower intensity and shorter duration, indicating that PIPR is a function of stimulus intensity, stimulus duration, and retinal area stimulated. The testing protocol can be refined with this new knowledge to target particular clinical populations.

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Cited by 46 publications

(62 citation statements)
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“…We noted two patterns of the early dilation component of the pupil response in mice and likewise, the human pupil responses described by Lei et al 27 also show two patterns depending on the stimulus conditions. The pupil responses to 1 second stimuli of red (0.1 to 400 cd/m 2 ) or low blue light (<1 cd/m 2 ) have a rapid dilation while the pupil response to 1 second blue stimuli higher than 1 cd/m 2 show a more prolonged constriction.…”
Section: Discussionsupporting
confidence: 86%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…We noted two patterns of the early dilation component of the pupil response in mice and likewise, the human pupil responses described by Lei et al 27 also show two patterns depending on the stimulus conditions. The pupil responses to 1 second stimuli of red (0.1 to 400 cd/m 2 ) or low blue light (<1 cd/m 2 ) have a rapid dilation while the pupil response to 1 second blue stimuli higher than 1 cd/m 2 show a more prolonged constriction.…”
Section: Discussionsupporting
confidence: 86%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…During the stimulus onset, in the lower intensity tested (14%) in the 11 healthy individuals, it is observable that the maximum constriction for the blue light is higher than the red one, as observed in other works [ 10 , 14 , 17 ]. In the higher intensity, this difference in the PLR curves while the stimuli are on is not visible.…”
Section: Discussionsupporting
confidence: 79%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The wavelength-dependent effect on constriction velocity may be related to the differential rod and cone sensitivity to the wavelength and mediated extrinsically via ipRGCs. 13 Consistent with previous studies, 43,44 pupil constriction velocity increased with increasing stimulus irradiance. 58,59 Our findings confirm for narrowband lights that, with increasing retinal irradiance, the magnitude of pupil constriction increases [58][59][60][61] and the transient PLR increases and the PLR latency shortens.…”
Section: Pupil Light Reflex During Light Stimulationsupporting
confidence: 88%
“…We report the intra-and interindividual variability of all current PIPR metrics. Another study reported a lower interindividual coefficient of variation for the 6-second PIPR than the plateau PIPR, 44 whereas our study showed a low CV ( 0.2) for both 6-second and plateau PIPR metrics compared to all other metrics. However, that study used a larger stimulus (608 3 908) and defined the plateau PIPR as the average PIPR from 10 to 30 seconds post stimulus; hence, it may not be comparable to our results.…”
Section: Post-illumination Pupil Responsecontrasting
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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