Human Reproduction Update
 2013
DOI: 10.1093/humupd/dmt010
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Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis

Fernando M. Reis
1
,
Felice Petraglia
2
,
Robert N. Taylor
3

Abstract: Estrogens and progestogens modulate chemotaxis and apoptosis in human endometrium and endometriotic cells and tissues. These endocrine and paracrine pathways are perturbed in women with endometriosis, contributing to inflammatory responses, abnormal tissue remodeling, therapeutic refractoriness and disease persistence. Ultimately, they promote adhesion formation and the clinical symptoms of pelvic pain and infertility. A more detailed understanding of the molecular mechanisms involved will offer new opportunit… Show more

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Cited by 272 publications

(226 citation statements)
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“…A distribution of COX2 in endometriotic lesions (Ota et al, 2001) and increased COX2 mRNA expression in a mix of endometriotic lesions (Bukulmez et al, 2008) also supported an augmented prostaglandin secretion in these tissues. As PLA2G2A also induces vascular endothelial cell migration (Rizzo et al, 2000), our data support the link between inflammation and angiogenesis in endometriosis (Reis et al, 2013).…”
Section: Discussionsupporting
confidence: 73%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…A distribution of COX2 in endometriotic lesions (Ota et al, 2001) and increased COX2 mRNA expression in a mix of endometriotic lesions (Bukulmez et al, 2008) also supported an augmented prostaglandin secretion in these tissues. As PLA2G2A also induces vascular endothelial cell migration (Rizzo et al, 2000), our data support the link between inflammation and angiogenesis in endometriosis (Reis et al, 2013).…”
Section: Discussionsupporting
confidence: 73%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Moreover, PCNA immunostaining appeared to be decreased in KO/KO mice and WT/WT mice treated with ISO-1. These data further support MIF pro-survival effects, its possible involvement in endometriotic cell resistance to apoptosis and its relevance to endometriosis as numerous alterations in the apoptotic pathways were detected in women with endometriosis, including a significant BCL2/BAX disequilibrium favoring the BCL2 survival pathway [54] – [56] .…”
Section: Discussionsupporting
confidence: 68%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…This perspective provides a coherent explanation for the marked heterogeneity observed among patients, including differences in age at onset, anatomical distribution of lesions, symptom severity, and risk of recurrence. It also supports the concept that endometriosis is not a static condition but a continuously evolving disorder, in which biological, environmental, and temporal factors converge to define individual disease phenotypes [ 109 , 110 , 111 , 112 ].…”
Section: A Systemic Disease Model Of Endometriosissupporting
confidence: 71%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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