BMJ
 2013
DOI: 10.1136/bmj.f185
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Early interventions to prevent psychosis: systematic review and meta-analysis

Matthew Stafford
1
,
Henry J. Jackson
2
,
Evan Mayo‐Wilson
3
et al.

Abstract: Objective To determine whether any psychological, pharmacological, or nutritional interventions can prevent or delay transition to psychotic disorders for people at high risk.Design Systematic review and meta-analysis.Data sources Embase, Medline, PreMedline, PsycINFO, and CENTRAL were searched to November 2011 without restriction to publication status. Review methodsRandomised trials comparing any psychological, pharmacological, nutritional, or combined intervention with usual services or another treatment. S… Show more

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Cited by 437 publications

(363 citation statements)
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“…Our results are consistent with other recent reviews showing that psychological approaches may reduce transition to psychosis, including for people with bipolar disorder, 87 and that family psychological interventions reduce relapse rates in both early and established schizophrenia. 88,89 Additionally, psychological interventions are the most effective interventions for people with major depression.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Our results are consistent with other recent reviews showing that psychological approaches may reduce transition to psychosis, including for people with bipolar disorder, 87 and that family psychological interventions reduce relapse rates in both early and established schizophrenia. 88,89 Additionally, psychological interventions are the most effective interventions for people with major depression.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Recent findings from the FT intervention sample showed that the intervention decreased parental harsh punishment and increased parental warmth which, in turn, decreased conduct disorder and callous-unemotional traits (i.e., lack of guilt, empathy, and deficient affect), respectively, in early adolescence (Pasalich et al 2016). Thus, the present findings support recent meta-analytic studies pointing to the efficacy of family therapy for the treatment of psychosis symptoms (e.g., Stafford et al 2013). Future research should examine whether parenting behaviors mediate the effect between early prevention interventions and later psychosis symptoms.…”
Section: Discussionsupporting
confidence: 90%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…We also showed that the mean number of CBT sessions attended by HR patients was 12, and that the majority of them (62%) did not drop out. These findings are in line with meta-analytical evidence indicating that an average of 11 sessions with good compliance (Stafford et al 2013) is required in RCTs of CBT interventions in HR samples. Only for a minority of OASIS patients did clinicians additionally prescribe an AP (17%) or AD (17%).…”
Section: Discussionsupporting
confidence: 89%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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