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. 2020 May;28(5):860-869.
doi: 10.1002/oby.22756. Epub 2020 Apr 9.

Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study

Lisa S Chow  1 , Emily N C Manoogian  2 , Alison Alvear  1 , Jason G Fleischer  2 , Honoree Thor  1 , Katrina Dietsche  1 , Qi Wang  3 , James S Hodges  3 , Nicholas Esch  1 , Samar Malaeb  1 , Tasma Harindhanavudhi  1 , K Sreekumaran Nair  4 , Satchidananda Panda  2 , Douglas G Mashek  1   5
Affiliations

Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study

Lisa S Chow et al. Obesity (Silver Spring). 2020 May.

Abstract

Objective: In contrast to intentionally restricting energy intake, restricting the eating window may be an option for treating obesity. By comparing time-restricted eating (TRE) with an unrestricted (non-TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.

Methods: Participants (17 women and 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m2 ) with a prolonged eating window (15.4 [0.9] hours) were randomized to TRE (n = 11: 8-hour window, unrestricted eating within window) versus non-TRE (n = 9: unrestricted eating) for 12 weeks. Weight, body composition (dual x-ray absorptiometry), lipids, blood pressure, 2-hour oral glucose tolerance, 2-week continuous glucose monitoring, and 2-week physical activity (actigraphy assessed) were measured during the pre- and end-intervention periods.

Results: The TRE group significantly reduced the eating window (end-intervention window: 9.9 [2.0] hours) compared with the non-TRE group (end-intervention window: 15.1 [1.1] hours) (P < 0.01). Compared with non-TRE, TRE decreased the number of eating occasions, weight, lean mass, and visceral fat (all P ≤ 0.05). Compared with preintervention measures, the TRE group reduced the number of eating occasions (-21.9% [30.1%]) and reduced weight (-3.7% [1.8%]), fat mass (-4% [2.9%]), lean mass (-3.0% [2.7%]), and visceral fat (-11.1% [13.4%]) (all P ≤ 0.05). Physical activity and metabolic measures remained unchanged.

Conclusions: In the setting of a randomized trial, TRE presents a simplified view of food intake that reduces weight.

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Figures

Figure 1:
Figure 1:
Participant Flow
Figure 2:
Figure 2:
Pre-intervention Eating Window Is Associated with BMI
Figure 3:
Figure 3:
Time of eating events in the non-TRE (A) and TRE group (B) Pre and End-Intervention. This figure depicts the clock hour for eating events at pre-intervention (orange; 2 weeks prior to randomization) and end-intervention (blue; 2 weeks prior to study conclusion) for each participant (Panel A: non-TRE, Panel B: TRE). Y axis: Clock hour for eating event (4=4AM, 24=midnight). X-axis: Each orange/blue combination represents an individual participant.
Figure 4:
Figure 4:
TRE Alters Body Composition. Average change in body weight, lean mass, fat mass, and visceral fat in the TRE vs. the non-TRE groups. Results reported as mean (SD). *indicates significance relative to TRE pre-intervention. † indicates significant relative to non-TRE group end-intervention.
Figure 5:
Figure 5:
Restriction of Eating Window Affects Body Composition
See this image and copyright information in PMC

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