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Review
. 2016 Dec 15:107:367-392.
doi: 10.1016/j.addr.2016.06.012. Epub 2016 Jun 26.

Physical and mechanical properties of PLA, and their functions in widespread applications - A comprehensive review

Shady Farah  1 , Daniel G Anderson  2 , Robert Langer  3
Affiliations
Review

Physical and mechanical properties of PLA, and their functions in widespread applications - A comprehensive review

Shady Farah et al. Adv Drug Deliv Rev. .

Abstract

Poly(lactic acid) (PLA), so far, is the most extensively researched and utilized biodegradable aliphatic polyester in human history. Due to its merits, PLA is a leading biomaterial for numerous applications in medicine as well as in industry replacing conventional petrochemical-based polymers. The main purpose of this review is to elaborate the mechanical and physical properties that affect its stability, processability, degradation, PLA-other polymers immiscibility, aging and recyclability, and therefore its potential suitability to fulfill specific application requirements. This review also summarizes variations in these properties during PLA processing (i.e. thermal degradation and recyclability), biodegradation, packaging and sterilization, and aging (i.e. weathering and hygrothermal). In addition, we discuss up-to-date strategies for PLA properties improvements including components and plasticizer blending, nucleation agent addition, and PLA modifications and nanoformulations. Incorporating better understanding of the role of these properties with available improvement strategies is the key for successful utilization of PLA and its copolymers/composites/blends to maximize their fit with worldwide application needs.

Keywords: Applications; Biodegradable polymers; PLA; Physical and mechanical properties; Polymer processing.

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