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. 2016 Jan-Mar;5(1):16-21.
doi: 10.4103/2279-042X.176556.

Prophylactic antiemetic effects of Midazolam, Ondansetron, and their combination after middle ear surgery

Azim Honarmand  1 , Mohammadreza Safavi  1 , Mansoureh Chegeni  1 , Anahita Hirmanpour  1 , Masoud Nazem  2 , Seyyad Hamid Sarizdi  1
Affiliations

Prophylactic antiemetic effects of Midazolam, Ondansetron, and their combination after middle ear surgery

Azim Honarmand et al. J Res Pharm Pract. 2016 Jan-Mar.

Abstract

Objective: The purpose of the present study was to evaluate the efficacy of midazolam-ondansetron combination in prevention of postoperative nausea and vomiting (PONV) after middle ear surgery and its comparison with using midazolam or ondansetron alone.

Methods: One hundred and forty patients were enrolled in four groups to receive midazolam 0.75 mg/kg in group M, ondansetron 4 mg in group O, midazolam 0.75 mg/kg and ondansetron 4 mg in group MO, and saline 0.90% in group S intravenously just before anesthesia. Assessment of nausea, vomiting, rescue antiemetic, and side effects of study drugs such as headache and dizziness was carried out postoperatively for 24 h.

Findings: The incidence of PONV was significantly smaller in group MO than group M and group O, while there was no significant difference between group M and group O during the first 24 h postoperatively. Requirement to the additional antiemetic was significantly more in group S (71.4%) compared to other groups, while in group MO (11.4%) was lower than group M (31.4%) and group O (34.3%).

Conclusion: Our study showed that prophylactic administration of midazolam 0.75 mg/kg combined with ondansetron 4 mg was more effective than using midazolam or ondansetron alone in prevention of PONV after middle ear surgery.

Keywords: Midazolam; Ondansetron; middle ear surgery; postoperative nausea and vomiting.

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