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Comment
. 2015 Jun;138(Pt 6):e353.
doi: 10.1093/brain/awu239. Epub 2014 Aug 22.

A new case of complete primary cerebellar agenesis: clinical and imaging findings in a living patient

Feng Yu  1 , Qing-jun Jiang  2 , Xi-yan Sun  3 , Rong-wei Zhang  1
Affiliations
Comment

A new case of complete primary cerebellar agenesis: clinical and imaging findings in a living patient

Feng Yu et al. Brain. 2015 Jun.
No abstract available

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Figures

Figure 1
Figure 1
(A) Consecutive axial CT images show a large low density in posterior fossa and no cerebellar tissue. (B) Consecutive T1-weighted sagittal MRI reveals that there is no recognizable cerebellar structure and the posterior fossa is filled by CSF with no mass effect. Mesencephalon, pons, and medulla oblongata were present. The mesencephalon had a normal aspect, and the Sylvian aqueduct seemed patent. The pons, medulla oblongata was attenuate and no hindbrain herniation. Tentorial attachment and straight sinus are normal. Supratentorially, the pattern of cortical gyri was normal as was the corpus callosum, aqueduct. The shape and relative proportions of the third ventricle and lateral ventricle were preserved and no hydrocephalus. (C and D) Consecutive axial and coronal T2-weighted MRI demonstrates no structures in posterior fossa, which means the absence of a cerebellum.
Figure 2
Figure 2
Magnetic resonance angiography demonstrates that the posterior inferior cerebellar artery, anterior inferior cerebellar artery and superior cerebellar artery are absent bilaterally, meaning the posterior fossa is avascular.
Figure 3
Figure 3
Diffusion tension imaging shows the ascending and descending fibres are integrated but no ponto-cerebellar fibres enter the cerebellum, which means complete lack of the efferent and afferent limbs of the cerebellum.
See this image and copyright information in PMC

Comment on

References

    1. Alkan O, Kizilkilic O, Yildirim T. Malformations of the midbrain and hindbrain: a retrospective study and review of the literature. Cerebellum. 2009;8:355–65. - PubMed
    1. Barkovich AJ, Millen KJ, Dobyns WB. A developmental classification of malformations of the brainstem. Ann Neurol. 2007;62:625–39. - PubMed
    1. Boyd CA. Cerebellar agenesis revisited. Brain. 2010;133(Pt 3):941–4. - PubMed
    1. Combettes M. Absence complète du curvelet, des pédoncules postérieus et de la proturbérance cérebrale chez une jeune fille morte dans sa onzième année. Bull Soc Anat Paris. 1831;5:148–57.
    1. Deniz T, Serap U, Omer I. Primary cerebellar agenesis-Chiari IV malformation. O.M.U. Tip Dergisi. 2002;19:213–6.