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. 2008 Dec;5(12):28-41.

General medical with depression drugs associated

Donald Rogers  1 , Ronald Pies
Affiliations

General medical with depression drugs associated

Donald Rogers et al. Psychiatry (Edgmont). 2008 Dec.

Abstract

Drug-induced depression has been the focus of intense scrutiny by the US Food and Drug Administration and has serious clinical and medicolegal implications. "Gold standard" studies of drug-induced depression-involving randomized, placebo-controlled design and direct assessment of depressive symptoms-are lacking. Based on the available literature, our review suggests that only a few types of drugs are strongly linked with induction of depression. However, the potential for idiosyncratic reactions-not necessarily detected in large-scale studies-suggests that particular caution and careful monitoring are warranted with several types of drugs, including isotretinoin, rimonabant, and alpha interferons.

Keywords: depressogenic; depressogenic drugs; drug-induced depression; iatrogenic depression; secondary depression.

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Figures

FIGURE 1
FIGURE 1
Naranjo causality scale
See this image and copyright information in PMC

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